DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a19 and Cyp3a2

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_695224.3	Gene:	Cyp3a2 / 266682	RGDID:	708379	Length:	504	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	146/512 - (28%)
Similarity:	245/512 - (47%)	Gaps:	63/512 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VVGVLTLVAWWVL------------QNYTYWKRRGIPHDPPNIPLGNTGELWRTMPLAGILKRTY 60
            ::..|||..|.:|            ..:..:|::|||...|...||.....::  .|.......|
  Rat     3 LLSALTLETWVLLAVILVLLYRLGTHRHGIFKKQGIPGPKPLPFLGTVLNYYK--GLGRFDMECY 65

  Fly    61 LKFRKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRD-FDKFHDRGVYHNEKD-DP---LTNNLA 120
            .|:     |...|.:........|.|.:.:|.||::: |      .|:.|.:| .|   :...::
  Rat    66 KKY-----GKIWGLFDGQTPVFAIMDTEMIKNVLVKECF------SVFTNRRDFGPVGIMGKAVS 119

  Fly   121 TIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTDIVSRFTSDV 185
            ..:.::||..|..|:.||||.::|.||..:...||.:::.:.:: :.:.:.:.:..:...::.||
  Rat   120 VAKDEEWKRYRALLSPTFTSGRLKEMFPIIEQYGDILVKYLKQE-AETGKPVTMKKVFGAYSMDV 183

  Fly   186 IGICAFGLKCNSLRDPKAEFVQMGYSALRERRHGWLVDLLIFGMPKLAVKLGFQFLLP------- 243
            |...:||:..:||.:||..||:.....||         ...|....|:|.| |.||.|
  Rat   184 ITSTSFGVNVDSLNNPKDPFVEKTKKLLR---------FDFFDPLFLSVVL-FPFLTPIYEMLNI 238

  Fly   244 ------SV---QKFYMKIVQDTIDYRMKRKVTRNDFMDTLIDMKQQYDKGDKENGLAFNEVAAQA 299
                  |:   |||..:|.:..:|.:.|.:|   ||:..:::.............|:..|:.||:
  Rat   239 CMFPKDSIAFFQKFVHRIKETRLDSKHKHRV---DFLQLMLNAHNNSKDEVSHKALSDVEIIAQS 300

  Fly   300 FVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQDLFYMEKVINES 364
            .:|..||:|..|:|:.|.||.||.:.|:|.||:.|||..|.. .....||.:.::.|::.|:||:
  Rat   301 VIFIFAGYETTSSTLSFVLYFLATHPDIQKKLQEEIDGALPS-KAPPTYDIVMEMEYLDMVLNET 364

  Fly   365 LRKHPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQVKK 429
            ||.:|:...|.|:..|..:...  .||..|:.|.:.|..:||||:.:|:||:|.||||.:|....
  Rat   365 LRLYPIGNRLERVCKKDIELDG--LFIPKGSVVTIPTYALHHDPQHWPKPEEFHPERFSKENKGS 427

  Fly   430 RPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMKYTINNLL 486
            .....:||||.|||||||:||..|.:.:.|..::.||.|:...:|.:|:|.:...:|
  Rat   428 IDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQAIL 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	138/476 (29%)
Cyp3a2	NP_695224.3	CYP3A	67..493	CDD:410743	132/446 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870