DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a19 and erg5

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_593788.2	Gene:	erg5 / 2542469	PomBaseID:	SPAC19A8.04	Length:	543	Species:	Schizosaccharomyces pombe

Alignment Length:	503	Identity:	106/503 - (21%)
Similarity:	193/503 - (38%)	Gaps:	109/503 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 TYWKRRGIPHDP-PNIPLGNTGELWRTMPLAGILKRTYLKFR-KQTDGPFAGFYLYAMKYIVITD 86
            :|..::|  |.| |...:...|....:|      |.|:.|:. |...||.:...::....::.::
pombe    46 SYQMQKG--HIPGPRFKIPFMGSFLDSM------KPTFEKYNAKWQTGPLSCVSVFHKFVVIASE 102

  Fly    87 VDFVKTVLIRDFDKFHDRGVYHNEKDDPLTNNLATIEGQKWKNLRQKLTHTFTSAKMKS------ 145
            .|..:.:|  :...:....|....|......|...::|:.....|:.|...||:..:.|
pombe   103 RDLARKIL--NSPSYVQPCVVDAGKKILKHTNWVFLDGRDHIEYRKGLNGLFTTRALASYLPAQE 165

  Fly   146 -----MFSTVL-----NVGDEMIRVVDEKISSSSQTLEVTDIVSRFTSDVIGICAFGLKCNSLRD 200
                 .|...|     :....||...|..:::|.:|                .|.:.:..::::.
pombe   166 AVYNKYFKEFLAHSKDDYAQYMIPFRDINVATSCRT----------------FCGYYISDDAIKH 214

  Fly   201 PKAEFVQMGYSALRERRHGWLVDLLIFGMPKLAVKLGFQFLLPSVQKFYMKIVQDTIDYRMKRK- 264
            ...|:.::  :|..|     ||:..|. :|...|..|.| ....|.:::||...::      ||
pombe   215 IADEYWKI--TAAME-----LVNFPIV-LPFTKVWYGIQ-SRKVVMRYFMKAAAES------RKN 264

  Fly   265 --------VTRNDFMDTLIDMKQQYDKGDKENG---------LAFNEVAAQAFVFFLAGFEAGST 312
                    ....:::..:|:.: :|...:||..         .:..|::.....|..|..:|.|:
pombe   265 MEAGNAPACMMEEWIHEMIETR-KYKSENKEGAEKPSVLIREFSDEEISLTFLSFLFASQDATSS 328

  Fly   313 TMGFTLYELACNQDVQDKLRAE--------IDSVLERYNGKLEYDSMQDLFYMEKVINESLRKHP 369
            .|.:....||.:.||..|:|.|        ||.       .|..|.|:.:.|...|:.|.||..|
pombe   329 AMTWLFQLLADHPDVLQKVREEQLRIRKGDIDV-------PLSLDLMEKMTYTRAVVKECLRLRP 386

  Fly   370 VVAHLARIATKPYQHS-----NPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQVKK 429
            .|..:      ||:..     .|.|.:.....|:.:..|..||.:.|||||.|.|:|:....:.:
pombe   387 PVLMV------PYRVKKAFPITPDYTVPKDAMVIPTLYGALHDSKVYPEPETFNPDRWAPNGLAE 445

  Fly   430 RPTCAFLPFGAGPRNCIGLRFGRMQVI--IGLALLIHNFRFELHPKTP 475
            :....::.||.||..|:|.|:....:|  ||.|.::.:::   |.:||
pombe   446 QSPKNWMVFGNGPHVCLGQRYAVNHLIACIGKASIMLDWK---HKRTP 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	104/495 (21%)
erg5	NP_593788.2	CypX	57..505	CDD:225035	102/490 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
TreeFam	0	0.000	Not matched by this tool.
	3	3.050