Protein Alignment Cyp6a19 and Cyp3a18

DIOPT Version :9

• Sequence 1: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_665725.2
• Gene: Cyp3a18 / 252931
• RGDID: 628709
• Length: 497
• Species: Rattus norvegicus
• Alignment Length: 536
• Identity: 162/536 - (30%)
• Similarity: 264/536 - (49%)
• Gaps: 72/536 - (13%)

  Fly     1 MAILLGLVVGVLTLVAWWVLQNYTY-------WKRRGIPHDPPNIPLGNT----GE-LWRTMPLA 53
            |.|:..|.:....|:|..::..|.|       :|:.||| .|..:||..|    |: :|:
  Rat     1 MEIIPNLSIETWVLLATSLMLFYIYGTYSHGLFKKLGIP-GPKPVPLFGTIFNYGDGMWK----- 59

  Fly    54 GILKRTYLKFRKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRD-FDKFHDRGVYHNEKDDP--- 114
             .....|.|:     |...|||.....::.|.|.:.:|.||::: :..|.:|..:     .|
  Rat    60 -FDDDCYKKY-----GKIWGFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRRCF-----GPMGF 113

  Fly   115 LTNNLATIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTDIVS 179
            :...:...|.::||.||..|:.||||.|:|.||..:...||.:::.: .:..:..:.:.:.||..
  Rat   114 MKKAITMSEDEEWKRLRTILSPTFTSGKLKEMFPLMRQYGDTLLKNL-RREEAKGEPINMKDIFG 177

  Fly   180 RFTSDVIGICAFGLKCNSLRDPKAEFVQMGYSALRERRHGWLVDLLIFGMPKLAVKLGFQFLLPS 244
            .::.|||...:||:..:||.:|:..|||.....|:         ..||....|:|.| |.||.|.
  Rat   178 AYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILK---------FQIFDPFLLSVVL-FPFLTPI 232

  Fly   245 VQ------------KFYMKIV----QDTIDYRMKRKVTRNDFMDTLIDMKQQYDKG-DKENGLAF 292
            .:            .|:.|.|    ::.:|...|.:|   ||:..:  |..|..|| :.:..|:.
  Rat   233 YEMLNFSIFPRQSMNFFKKFVKTMKKNRLDSNQKSRV---DFLQLM--MNTQNSKGQESQKALSD 292

  Fly   293 NEVAAQAFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQDLFYM 357
            .|:||||.:|...|::|.||::.|.:||||...:||.||:.|||..|.. ...:.||::.::.|:
  Rat   293 LEMAAQAIIFIFGGYDATSTSISFIMYELATRPNVQKKLQNEIDRALPN-KAPVTYDALMEMEYL 356

  Fly   358 EKVINESLRKHPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERF 422
            :.|:|||||.:|:...|.|::.|..:.:.  .||..||.|.:....:|.:||::.|||:|.||||
  Rat   357 DMVVNESLRLYPIATRLDRVSKKDVEING--VFIPKGTVVTIPIYPLHRNPEYWLEPEEFNPERF 419

  Fly   423 DEEQVKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMKYTINNLLL 487
            .:|.........:||||.|||||||:||..:.:.:.:..::.||..:...||.:|:|.: ...:.
  Rat   420 SKENKGSIDPYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKTQIPLKIS-RQPIF 483

  Fly   488 GSEGGIHLNITKVVRD 503
            ..||.|.|.:  |.||
  Rat   484 QPEGPIILKL--VSRD 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	148/488 (30%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	140/454 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.770