DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a19 and Tbxas1

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_036819.1	Gene:	Tbxas1 / 24886	RGDID:	3826	Length:	533	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	149/549 - (27%)
Similarity:	266/549 - (48%)	Gaps:	88/549 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ILLGLVVGVLTLVAWWVLQNYTYWKRRGIPHDPPNIPLGN----TGELWRTMPLAGILKRTYLKF 63
            :.:.|.|.:|.|:.|:....::..::.||.|..|:..:||    ....|          .::|:.
  Rat    16 VTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFRQGFW----------ESHLEL 70

  Fly    64 RKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDR---GVYHNEKDDP--LTNNLATIE 123
            |::. ||..|:||....||||:|.|.:|.||:.:|..|.:|   |:      :|  :.:::..:.
  Rat    71 RERY-GPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGL------EPKLIADSVLMLR 128

  Fly   124 GQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTDIVSRFTSDVIGI 188
            .::|:.:|..|...|:..|:..| :.:::...|::....:..::|....::......||::|:..
  Rat   129 DRRWEEVRGALMSAFSPEKLNEM-TPLISQACELLLSHLKHSAASGDAFDIQRCYCCFTTNVVAS 192

  Fly   189 CAFGLKCNSLRDPKAEFVQ-----MGYSALRERRHGWLVDLLIFGMPKLAVKLGFQFLLPSVQK- 247
            .|||::.||...|:..|||     ..:|..|.      :..||...|.:.|.|.  .:||:..:
  Rat   193 VAFGIEVNSQDAPEDPFVQHCQRVFAFSTPRP------LLALILSFPSIMVPLA--RILPNKNRD 249

  Fly   248 ----FYMKIVQDTIDYRMKR--KVTRNDFMDTLIDMKQQYDK-------------------GD-- 285
                |:..::::.|..|.|:  :..|.||:..::|.::....                   ||
  Rat   250 ELNGFFNTLIRNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMVTEALSSAECMGDPP 314

  Fly   286 -------KENGLAFNEVAAQAFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYN 343
                   ....|..:|:|.|||:|.:||.|..:.|:.|..|.||.:.:.|::|..|:|..:|::.
  Rat   315 QRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKHP 379

  Fly   344 GKLEYDSMQD-LFYMEKVINESLRKHPVVAHLARIATKPY----QHSNPKYFIEAGTGVLVSTLG 403
            .. ||.::|: |.|::.|:.|:||.:|......|.|.:..    ||      |.||:.:.::...
  Rat   380 AP-EYCNLQEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEVLGQH------IPAGSVLEIAVGA 437

  Fly   404 IHHDPEFYPEPEKFIPERFDEEQVKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRF 468
            :|||||.:|.||.|.||||..|...::....:||||||||:|:|:|.|.:.|.:.|..::|.|||
  Rat   438 LHHDPEHWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRF 502

  Fly   469 ELHPKTPVPMKYTINNLLLGSEGGIHLNI 497
            |..|:|.||::....:.|. .:.|:::.|
  Rat   503 EACPETQVPLQLESKSALC-PKNGVYVKI 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	141/516 (27%)
Tbxas1	NP_036819.1	p450	47..530	CDD:278495	140/516 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130979
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770