DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a19 and Tbxas1

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_035669.3	Gene:	Tbxas1 / 21391	MGIID:	98497	Length:	533	Species:	Mus musculus

Alignment Length:	540	Identity:	141/540 - (26%)
Similarity:	262/540 - (48%)	Gaps:	70/540 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ILLGLVVGVLTLVAWWVLQNYTYWKRRGIPHDPPNIPLGN----TGELWRTMPLAGILKRTYLKF 63
            :.:.|:|.:|.|:.|:.:..::..::.||.|..|:..:||    ....|.:.          |:.
Mouse    16 VTVTLLVALLALLKWYSMSAFSRLEKLGIRHPKPSPFVGNLMFFRQGFWESQ----------LEL 70

  Fly    64 RKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHNEKDDPLTNNLATIEGQKWK 128
            |::. ||..|:||....::||::.|.:|.||:.:|..|.:| :....:...:.:::..:..::|:
Mouse    71 RERY-GPLCGYYLGRRMHVVISEPDMIKQVLVENFSNFSNR-MASGLEPKMVADSVLLLRDRRWE 133

  Fly   129 NLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTDIVSRFTSDVIGICAFGL 193
            .:|..|..:|:..|:..| :.:::...|::....::.::|.....:......:|.||:...|||.
Mouse   134 EVRGALMSSFSPEKLDEM-TPLISQACELLVAHLKRYAASRDAFNIQRCYCCYTIDVVASVAFGT 197

  Fly   194 KCNSLRDPKAEFVQMGYSALRERRHGWL-----VDLLIFGMPKLAVKLGFQFLLPSVQK-----F 248
            :.:|...|:..|||      ..||....     :.:||...|.:.|.|.  .:||:..:     |
Mouse   198 QVDSQNSPEDPFVQ------HCRRASTFCIPRPLLVLILSFPSIMVPLA--RILPNKNRDELNGF 254

  Fly   249 YMKIVQDTIDYRMKR--KVTRNDFMDTLIDMK----------------------------QQYDK 283
            :..::::.|..|.::  :..|.||:..::|.:                            |:...
Mouse   255 FNTLIRNVIALRDQQAAEERRRDFLQMVLDAQHSMNSVGVEGFDMVPESLSSSECTKEPPQRCHP 319

  Fly   284 GDKENGLAFNEVAAQAFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEY 348
            .........:|:..|||:|.:||.|..:.|:.|..|.||.:.|.|::|..|:|..:.::... ||
Mouse   320 TSTSKPFTVDEIVGQAFLFLIAGHEVITNTLSFITYLLATHPDCQERLLKEVDLFMGKHPAP-EY 383

  Fly   349 DSMQD-LFYMEKVINESLRKHPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYP 412
            .|:|: |.|::.||:|:||.:|......|.|.:..:....:  |.|||.:.::...:|||||.:|
Mouse   384 HSLQEGLPYLDMVISETLRMYPPAFRFTREAAQDCEVLGQR--IPAGTVLEIAVGALHHDPEHWP 446

  Fly   413 EPEKFIPERFDEEQVKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVP 477
            .||.|.||||..|...:|....:||||||||:|:|:|.|.:.|.:.:..::|.||||..|:|.||
Mouse   447 NPETFDPERFTAEARLQRRPFTYLPFGAGPRSCLGVRLGLLVVKLTILQVLHKFRFEASPETQVP 511

  Fly   478 MKYTINNLLLGSEGGIHLNI 497
            ::.. :...||.:.|:::.|
Mouse   512 LQLE-SKSALGPKNGVYIKI 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	133/507 (26%)
Tbxas1	NP_035669.3	p450	47..528	CDD:365848	132/505 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130979
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.720