Protein Alignment Cyp6a19 and CYP4Z1

DIOPT Version :9

• Sequence 1: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_835235.1
• Gene: CYP4Z1 / 199974
• HGNCID: 20583
• Length: 505
• Species: Homo sapiens
• Alignment Length: 468
• Identity: 133/468 - (28%)
• Similarity: 215/468 - (45%)
• Gaps: 84/468 - (17%)

  Fly    69 GPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHNEKDDPLTNNLATIEGQKWKNLRQK 133
            |||..|:       .:.|.|:.|.:|.|...|   ..|.|...:..:...|.|::|.|||..||.
Human    85 GPFTMFF-------SVHDPDYAKILLKRQDPK---SAVSHKILESWVGRGLVTLDGSKWKKHRQI 139

  Fly   134 LTHTFTSAKMKSMFSTVLNVGDEMIRVV----DEKISSSSQTLEVTDIVSRFTSDVIGICAF--- 191
            :...|..:.:| :|.|:::   |.:|::    :|.|:.:|: ||:...||..|.|.|..|||
Human   140 VKPGFNISILK-IFITMMS---ESVRMMLNKWEEHIAQNSR-LELFQHVSLMTLDSIMKCAFSHQ 199

  Fly   192 -GLKCNSLRDP--KAEFVQMGYSALRERR------HGWLVDLLIFGMPKLAVKLGFQF------- 240
             .::.:|..|.  ||.|   ..|.:..:|      |..||               |:|
Human   200 GSIQLDSTLDSYLKAVF---NLSKISNQRMNNFLHHNDLV---------------FKFSSQGQIF 246

  Fly   241 --LLPSVQKFYMKIVQD---TIDYRMKRKVT---RNDFMDTLIDMKQQYDKGDKENGLAFNEVAA 297
              ....:.:|..|::||   ::..::|:..|   |.||:|.|:..|       .||...|:|...
Human   247 SKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAK-------SENTKDFSEADL 304

  Fly   298 QAFV--FFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQDLFYMEKV 360
            ||.|  |..||.:..|:.:.:.||.||...:.|.:.|.||..:|.. ...:.::.:..:.|....
Human   305 QAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGD-GSSITWEHLSQMPYTTMC 368

  Fly   361 INESLRKHPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEE 425
            |.|.||.:..|.:::|:..||....:.: .:.||..|.::...:||:|.|:.:|:.|.|.||..|
Human   369 IKECLRLYAPVVNISRLLDKPITFPDGR-SLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRE 432

  Fly   426 QVKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFEL---HPKTPVPMKYTINNLLL 487
            ..:|....||:||.||.|||||..|..::..:.:||.:  .||:|   |.:.|.|    :..::|
Human   433 NSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTL--LRFKLAPDHSRPPQP----VRQVVL 491

  Fly   488 GSEGGIHLNITKV 500
            .|:.|||:...||
Human   492 KSKNGIHVFAKKV 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	130/461 (28%)
CYP4Z1	NP_835235.1	p450	47..500	CDD:278495	131/462 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900