Protein Alignment Cyp6a19 and CYP4A11

DIOPT Version :10

• Sequence 1: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_000769.2
• Gene: CYP4A11 / 1579
• HGNCID: 2642
• Length: 519
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 147/534 - (27%)
• Similarity: 234/534 - (43%)
• Gaps: 72/534 - (13%)

  Fly     4 LLGLVVGVLTLVAWWVL--------QNYTY--WKRRGI---PHDPPNIPLGNTGELWRTMPLAGI 55
            |||.|.|:|...:..:|        |.|.:  |..:.:   |..|.:...|:..||.:...|..|
Human    11 LLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQELQQDQELQRI 75

  Fly    56 LKRTYLKFRKQTDGPFAGFYLYAMKY-IVITDVDFVKTVLIRDFDKFHDRGVYHNEKDDP-LTNN 118
            .|..      :|.......:|:..|. :.:.|.|::|.:|.|...|.|  |.|....  | :...
Human    76 QKWV------ETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSH--GSYRFLA--PWIGYG 130

  Fly   119 LATIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVD--EKISSSSQTLEVTDIVSRF 181
            |..:.||.|...|:.||..|....:|.....   :.|.:..::|  |::......|||...||..
Human   131 LLLLNGQTWFQHRRMLTPAFHYDILKPYVGL---MADSVRVMLDKWEELLGQDSPLEVFQHVSLM 192

  Fly   182 TSDVIGICAFGLKCNSLRDPKAE-FVQ-------MGYSALRERRH--GWLVDLLIFG-MPKLAVK 235
            |.|.|..|||..:.:...|..:: ::|       :.:|.:|...|  ..:..|...| ....|.:
Human   193 TLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQ 257

  Fly   236 LGFQFLLPSVQKFYMKIVQDTIDYRMKRKVTRNDFMDTLIDMKQQYDKGDKENG--LAFNEVAAQ 298
            |..|.....:|....::.::....::||| ...||:|.|:..|.       |||  |:..::.|:
Human   258 LAHQHTDQVIQLRKAQLQKEGELEKIKRK-RHLDFLDILLLAKM-------ENGSILSDKDLRAE 314

  Fly   299 AFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQDLFYMEKVINE 363
            ...|...|.:..::.:.:.||.||.:...|::.|.||.|:|.. ...:.::.:..:.|....|.|
Human   315 VDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGD-GASITWNHLDQMPYTTMCIKE 378

  Fly   364 SLRKHPVVAHLAR----IATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDE 424
            :||.:|.|..:.|    ..|.|...|.||     |..||:|..|:||:|:.:|.||.|.|.||..
Human   379 ALRLYPPVPGIGRELSTPVTFPDGRSLPK-----GIMVLLSIYGLHHNPKVWPNPEVFDPFRFAP 438

  Fly   425 EQVKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHP---KTPVPMKYTINNLL 486
            ...:.  :.|||||..|.|||||.:|...::.:..||.:  .||||.|   :.|:|    |..|:
Human   439 GSAQH--SHAFLPFSGGSRNCIGKQFAMNELKVATALTL--LRFELLPDPTRIPIP----IARLV 495

  Fly   487 LGSEGGIHLNITKV 500
            |.|:.||||.:.::
Human   496 LKSKNGIHLRLRRL 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	CYP6-like	67..494	CDD:410679	126/450 (28%)
CYP4A11	NP_000769.2	CYP4B-like	74..505	CDD:410771	130/465 (28%)