Protein Alignment Cyp6a19 and CYP3A4

DIOPT Version :9

• Sequence 1: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 150/525 - (28%)
• Similarity: 257/525 - (48%)
• Gaps: 81/525 - (15%)

  Fly     1 MAILLGLVVGVLTLVAWWVLQNYTY-------WKRRGIPHDPPNIPLGNT--------------- 43
            ||::..|.:....|:|..::..|.|       :|:.|||...|...|||.
Human     1 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECH 65

  Fly    44 ---GELWRTMPLAGILKRTYLKFRKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRD-FDKFHDR 104
               |::|                         |||......:.|||.|.:||||::: :..|.:|
Human    66 KKYGKVW-------------------------GFYDGQQPVLAITDPDMIKTVLVKECYSVFTNR 105

  Fly   105 GVYHNEKDDP---LTNNLATIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKIS 166
            ..:     .|   :.:.::..|.::||.||..|:.||||.|:|.|...:...||.::|.: .:.:
Human   106 RPF-----GPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL-RREA 164

  Fly   167 SSSQTLEVTDIVSRFTSDVIGICAFGLKCNSLRDPKAEFVQMGYSALR-ERRHGWLVDLLIFG-- 228
            .:.:.:.:.|:...::.|||...:||:..:||.:|:..||:.....|| :....:.:.:.:|.
Human   165 ETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFL 229

  Fly   229 MPKLAV-------KLGFQFLLPSVQKFYMKIVQDTIDYRMKRKVTRNDFMDTLIDMKQQYDKGDK 286
            :|.|.|       :....||..||::.....::||..:|:       ||:..:|| .|...:.:.
Human   230 IPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRV-------DFLQLMID-SQNSKETES 286

  Fly   287 ENGLAFNEVAAQAFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSM 351
            ...|:..|:.||:.:|..||:|..|:.:.|.:||||.:.|||.||:.|||:||.. .....||::
Human   287 HKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN-KAPPTYDTV 350

  Fly   352 QDLFYMEKVINESLRKHPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEK 416
            ..:.|::.|:||:||..|:...|.|:..|..:.:.  .||..|..|::.:..:|.||:::.||||
Human   351 LQMEYLDMVVNETLRLFPIAMRLERVCKKDVEING--MFIPKGVVVMIPSYALHRDPKYWTEPEK 413

  Fly   417 FIPERFDEEQVKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMKYT 481
            |:||||.::.........:.|||:|||||||:||..|.:.:.|..::.||.|:...:|.:|:|.:
Human   414 FLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS 478

  Fly   482 INNLL 486
            :..||
Human   479 LGGLL 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	140/487 (29%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	140/487 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820