DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a19 and CYP3A7

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_000756.3	Gene:	CYP3A7 / 1551	HGNCID:	2640	Length:	503	Species:	Homo sapiens

Alignment Length:	515	Identity:	157/515 - (30%)
Similarity:	257/515 - (49%)	Gaps:	59/515 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAILLGLVVGVLTLVAWWVLQNYTY-------WKRRGIPHDPPNIPLGNTGEL----WRTMPLAG 54
            |.::..|.|....|:|..::..|.|       :|:.|||...|...|||....    | |..:
Human     1 MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYW-TFDM-- 62

  Fly    55 ILKRTYLKFRKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRD-FDKFHDRGVYHNEKDDP---L 115
               ..|.|:||     ..|.|......:.|||.|.:||||::: :..|.:|..:     .|   :
Human    63 ---ECYKKYRK-----VWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPF-----GPVGFM 114

  Fly   116 TNNLATIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTDIVSR 180
            .|.::..|.::||.:|..|:.||||.|:|.|...:...||.::|.: .:.:.:.:.:.:..:...
Human   115 KNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL-RREAETGKPVTLKHVFGA 178

  Fly   181 FTSDVIGICAFGLKCNSLRDPKAEFVQMGYSALRERRHGWLVDLLIFGMPKLAVKLGFQFLLP-- 243
            ::.|||...:||:..:||.:|:..||:.....||...    :|..:     |::|: |.||.|
Human   179 YSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNP----LDPFV-----LSIKV-FPFLTPIL 233

  Fly   244 ----------SVQKFYMKIVQDTIDYRMKR-KVTRNDFMDTLIDMKQQYDKGDKENGLAFNEVAA 297
                      .|..|..|.|:...:.|:|. :..|.||:..:||.:...| .:....|:..|:.|
Human   234 EALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKD-SETHKALSDLELMA 297

  Fly   298 QAFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQDLFYMEKVIN 362
            |:.:|..||:|..|:.:.|.:||||.:.|||.|::.|||:||.. .....||::..|.|::.|:|
Human   298 QSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPN-KAPPTYDTVLQLEYLDMVVN 361

  Fly   363 ESLRKHPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQV 427
            |:||..||...|.|:..|..:.:.  .||..|..|::.:..:||||:::.|||||:||||.::..
Human   362 ETLRLFPVAMRLERVCKKDVEING--MFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNK 424

  Fly   428 KKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMKYTINNLLL 487
            .......:.|||:|||||||:||..:.:.:.|..::.||.|:...:|.:|:|.....|||
Human   425 DNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLL 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	147/477 (31%)
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	147/477 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820