DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a19 and Cyp4a10

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_034141.3	Gene:	Cyp4a10 / 13117	MGIID:	88611	Length:	509	Species:	Mus musculus

Alignment Length:	464	Identity:	126/464 - (27%)
Similarity:	206/464 - (44%)	Gaps:	74/464 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 FAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHNEKDDPLTN------------NLATIE 123
            |..::..:..|:.:.|.|::|.:|.|               .||..|            .|..:.
Mouse    85 FPRWFWGSKAYLTVYDPDYMKVILGR---------------SDPKANGAYRLLAPWIGYGLLLLN 134

  Fly   124 GQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVD--EKISSSSQTLEVTDIVSRFTSDVI 186
            ||.|...|:.||..|....:|..   |.|:.|.:..::|  |:::....::|:...:|..|.|.:
Mouse   135 GQPWFQHRRMLTPAFHYDILKPY---VKNMADSIRLMLDKWERLADQDSSIEIFQHISLMTLDTV 196

  Fly   187 GICAFGLKCNSLRDPK--------AEFVQMGYSALRE--RRHGWLVDLLIFG-MPKLAVKLGFQF 240
            ..|||..|.:...|..        .:...:.:|.:|.  .::..:..|...| :.|.|.:|....
Mouse   197 MKCAFSHKGSVQVDGNYRTYLQAIGDLNNLFHSRVRNIFHQNDTIYKLSSNGRLAKQACQLAHDH 261

  Fly   241 LLPSVQKFYMKIVQDTIDYRMKRKVTRNDFMDTLIDMKQQYDKGDKENG--LAFNEVAAQAFVFF 303
             ...|.|.....:||..:....:|..|.||:|.|:..:.       |||  ::..::.|:...|.
Mouse   262 -TDGVIKLRKDQLQDEGELEKIKKKRRLDFLDILLFARM-------ENGDSMSDKDLRAEVDTFM 318

  Fly   304 LAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQDLFYMEKVINESLRKH 368
            ..|.:..::.:.:..|.||.:.|.|.:.|.|:.|:|.. ...:.:|.:..:.|....|.|:||.:
Mouse   319 FEGHDTTASGVSWIFYALATHPDHQQRCREEVQSLLGD-GSSITWDHLDQIPYTTMCIKEALRLY 382

  Fly   369 P----VVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQVKK 429
            |    :|..|:...|.|...|.||     |..|.:|..|:||:|:.:|.||.|.|.||..:  ..
Mouse   383 PPVPGIVRELSTSVTFPDGRSLPK-----GVQVTLSIYGLHHNPKVWPNPEVFDPSRFAPD--SP 440

  Fly   430 RPTCAFLPFGAGPRNCIGLRF--GRMQVIIGLALLIHNFRFELHP-KTPVPMKYTINNLLLGSEG 491
            |.:.:||||..|.|||||.:|  ..::||:.|.||    ||||.| .|.|||  .:..|:|.|:.
Mouse   441 RHSHSFLPFSGGARNCIGKQFAMSELKVIVALTLL----RFELLPDPTRVPM--PLARLVLKSKN 499

  Fly   492 GIHLNITKV 500
            ||:|::.|:
Mouse   500 GIYLHLKKL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	124/457 (27%)
Cyp4a10	NP_034141.3	p450	52..503	CDD:278495	124/457 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900