Protein Alignment Cyp6a19 and Cyp46a1

DIOPT Version :10

• Sequence 1: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_034140.1
• Gene: Cyp46a1 / 13116
• MGIID: 1341877
• Length: 500
• Species: Mus musculus
• Alignment Length: 495
• Identity: 119/495 - (24%)
• Similarity: 225/495 - (45%)
• Gaps: 65/495 - (13%)

  Fly     7 LVVGVLTLVAWWVLQNYTYWKRRGIPHDP----PNIPLGNTGELWRTMPLAG-ILKRTYLKFRKQ 66
            |::|...|:|:.:...:.:..|....|.|    |:..||:....|:.....| :|:..:|.:.|:
Mouse     6 LLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPYFWKKDEDCGRVLQDVFLDWAKK 70

  Fly    67 TDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHNEKDDPLTNNLATIEGQ------ 125
            . ||.....::....:::|..:.||..|:.  .|::        ||..:...|.|:.|:
Mouse    71 Y-GPVVRVNVFYKTSVIVTSPESVKKFLMS--TKYN--------KDSKMYRALQTVFGERLFGQG 124

  Fly   126 --------KWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQT-LEVTDIVSRF 181
                    :|...|:.:...|:.:.:.|:..|.....::::.:::.|  :..|| :.:.|:::..
Mouse   125 LVSECDYGRWYKQRKVMDLAFSRSSLVSLMETFNEKAEQLVEILEAK--ADGQTPVSMQDMLTCA 187

  Fly   182 TSDVIGICAFGLKCNSL---RDPKAEFVQM---GYSALRERRHGWLVDLLIFGMPKLAVKLGFQF 240
            |.|::...|||::.:.|   :.|.::.|::   |.||.|        :.|...||      |.:.
Mouse   188 TIDILAKAAFGMETSMLLGAQKPLSQAVKVMLEGISASR--------NTLAKFMP------GKRK 238

  Fly   241 LLPSVQKFYMKIVQDTIDYRMKRKVTRNDFMDTLIDMKQQYDKGDKENGLAFNEVAAQAFV-FFL 304
            .|..:::....:.|...|:..:|:.......|...|:..|..|.  |.|...:||....|| ||:
Mouse   239 QLREIRESIRLLRQVGKDWVQRRREALKRGEDMPADILTQILKA--EEGAQDDEVLLDNFVTFFI 301

  Fly   305 AGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVL--ERYNGKLEYDSMQDLFYMEKVINESLRK 367
            ||.|..:..:.||:.||:...::..:|:||:|.|:  :|:   |:|:.:..|.|:.:|:.||||.
Mouse   302 AGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRH---LDYEDLGRLQYLSQVLKESLRL 363

  Fly   368 HPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQVKKRPT 432
            :|......|:..:.......:  :...|.:|.||..:.....::.:|..|.|:||.....|.|.|
Mouse   364 YPPAWGTFRLLEEETLIDGVR--VPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFT 426

  Fly   433 CAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHP 472
              :.||..|.|:|||.:|.:|:|.:.:|.|:....|.|.|
Mouse   427 --YFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRIEFRLVP 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	CYP6-like	67..494	CDD:410679	104/430 (24%)
Cyp46a1	NP_034140.1	CYP46A1-like	61..484	CDD:410706	106/440 (24%)