DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a19 and Cyp3a13

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus

Alignment Length:	510	Identity:	152/510 - (29%)
Similarity:	250/510 - (49%)	Gaps:	70/510 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVVGVLTLVAWWVLQNYTYWKRRGIPHDPPNIPLGNTGELWRTMPLAGILKRTYLKFRK---QTD 68
            |:...|.|:..:...::..:|:.|||...|             :|..|    |.|.::|   :.|
Mouse    14 LLATSLVLLYLYGTHSHGIFKKLGIPGPKP-------------LPFLG----TILAYQKGFWECD 61

  Fly    69 -------GPFAGFYLYAMKYIVITDVDFVKTVLIRD-FDKFHDR------GVYHNEKDDPLTNNL 119
                   |...|.|......:.|||.|.:||||::: :..|.:|      |:        |...:
Mouse    62 IQCHKKYGKMWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRRFGPVGI--------LKKAI 118

  Fly   120 ATIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTDIVSRFTSD 184
            :..|.::||.:|..|:.||||.::|.||..:....|.::|.:.:.:.....| .:.||...::.|
Mouse   119 SISENEEWKRIRALLSPTFTSGRLKEMFPIINQFTDVLVRNMRQGLGEGKPT-SMKDIFGAYSMD 182

  Fly   185 VIGICAFGLKCNSLRDPKAEFVQMGYSALRERRHGWLVDLLIFGMPKLAVKLGFQFLLP------ 243
            ||...:||:..:||.:|:..||:    .:::     |:...||....|:|.| |.||.|
Mouse   183 VITATSFGVNIDSLNNPQDPFVE----KIKK-----LLKFDIFDPLFLSVTL-FPFLTPVFDALN 237

  Fly   244 ------SVQKFYMKIVQDTIDYRMKRK-VTRNDFMDTLIDMKQQYDKGDKENGLAFNEVAAQAFV 301
                  .|..|:...|:...:.|||.| ..|.||:..:|: .|.|...:....|:..|:.||:.:
Mouse   238 VSLFPRDVISFFTTSVERMKENRMKEKEKQRVDFLQLMIN-SQNYKTKESHKALSDVEIVAQSVI 301

  Fly   302 FFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQDLFYMEKVINESLR 366
            |..||:|..|:.:.|.||.||.:.|||.||:.|||:.|.. .....||::..:.|::.|:||:||
Mouse   302 FIFAGYETTSSALSFALYLLAIHPDVQKKLQDEIDAALPN-KAPATYDTLLQMEYLDMVVNETLR 365

  Fly   367 KHPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQVKKRP 431
            .:|:...|.|:.....:.:.  .||..||.|::.|..:|.||:::||||:|.||||.::......
Mouse   366 LYPIAGRLERVCKTDVEING--LFIPKGTVVMIPTFALHKDPKYWPEPEEFRPERFSKKNQDSIN 428

  Fly   432 TCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMKYTINNLL 486
            ...:||||:|||||||:||..:.:.:.|..::.||..:...:|.:|:|.:...||
Mouse   429 PYMYLPFGSGPRNCIGMRFALINMKVALVRVLQNFTVQPCKETEIPLKLSKQGLL 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	146/485 (30%)
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	146/485 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.710