Protein Alignment Cyp6a19 and CYP46A1

DIOPT Version :10

• Sequence 1: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Alignment Length: 504
• Identity: 115/504 - (22%)
• Similarity: 227/504 - (45%)
• Gaps: 83/504 - (16%)

  Fly     7 LVVGVLTLVAWWVLQNYTYWKRRGIPHDP----PNIPLGNTGELWRTMPLAG-ILKRTYLKFRKQ 66
            |::|...|:|:.:...:.:..|....|.|    |:..||:....|:...:.| :|:..:|.:.|:
Human     6 LLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKK 70

  Fly    67 TDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHNEKDDPLTNNLATIEG------- 124
            . ||.....::....:::|..:.||..|:.  .|::        ||..:...|.|:.|
Human    71 Y-GPVVRVNVFHKTSVIVTSPESVKKFLMS--TKYN--------KDSKMYRALQTVFGERLFGQG 124

  Fly   125 -------QKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQT-LEVTDIVSRF 181
                   ::|...|:.:...|:.:.:.|:..|.....::::.:::.|  :..|| :.:.|:::..
Human   125 LVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAK--ADGQTPVSMQDMLTYT 187

  Fly   182 TSDVIGICAFGLKCNSL---RDPKAEFVQMGYSALRERRHGWLVDLLIFGMPKLAVKLGFQFLLP 243
            ..|::...|||::.:.|   :.|.::.|::....:...|:            .||.      .||
Human   188 AMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRN------------TLAK------FLP 234

  Fly   244 SVQKFYMKIVQDTIDYRMKRKVTRNDFMDTLIDMKQQYDKGDK------------ENGLAFNEVA 296
            ..:| .::.|:::|  |..|:|.|    |.:...::...:|::            |.|...:|..
Human   235 GKRK-QLREVRESI--RFLRQVGR----DWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGL 292

  Fly   297 AQAFV-FFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVL--ERYNGKLEYDSMQDLFYME 358
            ...|| ||:||.|..:..:.||:.||:...::..:|:||:|.|:  :||   |:::.:..|.|:.
Human   293 LDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRY---LDFEDLGRLQYLS 354

  Fly   359 KVINESLRKHPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFD 423
            :|:.||||.:|......|:..:.......:  :...|.:|.||..:.....::.:|..|.|:||.
Human   355 QVLKESLRLYPPAWGTFRLLEEETLIDGVR--VPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFG 417

  Fly   424 EEQVKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHP 472
            ....|.|.|  :.||..|.|:|||.:|.:|:|.:.:|.|:....|.|.|
Human   418 PGAPKPRFT--YFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVP 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	CYP6-like	67..494	CDD:410679	100/439 (23%)
CYP46A1	NP_006659.1	CYP46A1-like	61..484	CDD:410706	102/449 (23%)