DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a19 and Cyp4f15

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_598888.1	Gene:	Cyp4f15 / 106648	MGIID:	2146921	Length:	534	Species:	Mus musculus

Alignment Length:	531	Identity:	146/531 - (27%)
Similarity:	236/531 - (44%)	Gaps:	64/531 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLGLVVGVLTLVAWWVLQNYTYWKRRGIPHDPPNIPLGN--TGELWRTMPLAGILKR------TY 60
            ||.|::|...|:|..:.|.|.:::......|.|..|..|  .|.|....|....||.      ||
Mouse    25 LLLLLIGASWLLARVLTQTYIFYRTYHHLCDFPQPPKWNWFLGHLGMITPTEHGLKEVTNLVATY 89

  Fly    61 LKFRKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHNEKDDPLTNNLATIEGQ 125
            .:......||.       :..|.:...|.:::||...........|:::.....|.:.|...:|.
Mouse    90 PQGFMTWLGPI-------IPIITLCHPDIIRSVLNASASVALKEVVFYSFLKPWLGDGLLLSDGD 147

  Fly   126 KWKNLRQKLTHTFTSAKMK---SMFSTVLNVGDEMIRVVDEKISSSSQTLEVTDIVSRFTSDVIG 187
            ||.:.|:.||..|....:|   .:|:...|:   |........|..|..|:|.:.:|..|.|.:.
Mouse   148 KWSSHRRMLTPAFHFNILKPYVKIFNDSTNI---MHAKWQHLASGGSARLDVFENISLMTLDSLQ 209

  Fly   188 ICAFGLKCNSLRDPKAEFVQ--MGYSALRERRHGWLVDLLIFGMPKLAVKLGFQF--LLPSVQKF 248
            .|.|....|...:| :|::.  :..|||..:|:..|: |.|..:.:|... |.:|  ....|..|
Mouse   210 KCVFSFDSNCQENP-SEYISAILELSALVTKRYHQLL-LHIDSLYQLTCS-GRRFHKACHLVHSF 271

  Fly   249 YMKIVQD---TID-------YRMKRKVTRNDFMDTLIDMKQQYDKGDKENGLAFNEVAAQAFVFF 303
            ...::||   |:.       .:.|.|....||:|.|:..|   |:..||  |:..::.|:|..|.
Mouse   272 TDAVIQDRRRTLPSKHEDDVLKAKAKSKTLDFIDVLLLSK---DEDGKE--LSDEDIRAEADTFM 331

  Fly   304 LAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVL-ERYNGKLE-------YDSMQDLFYMEKV 360
            ..|.:..::.:.:.||.||.:.:.|::.|.|:..:| :|.:.::|       .|.:..|.::...
Mouse   332 FEGHDTTASGLSWILYNLARHPEYQERCRQEVQELLRDRESTEIECSCAVFLRDDLAQLPFLTMC 396

  Fly   361 INESLRKHPVVAHLARIATK----PYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPER 421
            |.||||.||.|..::|..|:    |.....||     |...:::....||:|..:|:||.:.|.|
Mouse   397 IKESLRLHPPVTVISRRCTQDIVLPDGRVIPK-----GVICIINIFATHHNPTVWPDPEVYDPFR 456

  Fly   422 FDEEQVKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMKYTINNLL 486
            ||.|.:|.|...||:||.||||||||..|...::.:.|||.:  .||.:.|....|.:..  .|:
Mouse   457 FDPENIKDRSPLAFIPFSAGPRNCIGQTFAMNEMKVALALTL--LRFRVLPDDKEPRRKP--ELI 517

  Fly   487 LGSEGGIHLNI 497
            |.:|||:.|.:
Mouse   518 LRAEGGLWLRV 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	137/499 (27%)
Cyp4f15	NP_598888.1	p450	57..526	CDD:278495	136/495 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900