Protein Alignment Cyp6a19 and CYP3A7-CYP3A51P

DIOPT Version :10

• Sequence 1: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_001243426.2
• Gene: CYP3A7-CYP3A51P / 100861540
• HGNCID: 51504
• Length: 535
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 157/515 - (30%)
• Similarity: 257/515 - (49%)
• Gaps: 59/515 - (11%)

  Fly     1 MAILLGLVVGVLTLVAWWVLQNYTY-------WKRRGIPHDPPNIPLGNTGEL----WRTMPLAG 54
            |.::..|.|....|:|..::..|.|       :|:.|||...|...|||....    | |..:
Human     1 MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYW-TFDM-- 62

  Fly    55 ILKRTYLKFRKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRD-FDKFHDRGVYHNEKDDP---L 115
               ..|.|:||     ..|.|......:.|||.|.:||||::: :..|.:|..:     .|   :
Human    63 ---ECYKKYRK-----VWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPF-----GPVGFM 114

  Fly   116 TNNLATIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTDIVSR 180
            .|.::..|.::||.:|..|:.||||.|:|.|...:...||.::|.: .:.:.:.:.:.:..:...
Human   115 KNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL-RREAETGKPVTLKHVFGA 178

  Fly   181 FTSDVIGICAFGLKCNSLRDPKAEFVQMGYSALRERRHGWLVDLLIFGMPKLAVKLGFQFLLP-- 243
            ::.|||...:||:..:||.:|:..||:.....||...    :|..:     |::|: |.||.|
Human   179 YSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNP----LDPFV-----LSIKV-FPFLTPIL 233

  Fly   244 ----------SVQKFYMKIVQDTIDYRMKR-KVTRNDFMDTLIDMKQQYDKGDKENGLAFNEVAA 297
                      .|..|..|.|:...:.|:|. :..|.||:..:||.:...| .:....|:..|:.|
Human   234 EALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKD-SETHKALSDLELMA 297

  Fly   298 QAFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQDLFYMEKVIN 362
            |:.:|..||:|..|:.:.|.:||||.:.|||.|::.|||:||.. .....||::..|.|::.|:|
Human   298 QSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPN-KAPPTYDTVLQLEYLDMVVN 361

  Fly   363 ESLRKHPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQV 427
            |:||..||...|.|:..|..:.:.  .||..|..|::.:..:||||:::.|||||:||||.::..
Human   362 ETLRLFPVAMRLERVCKKDVEING--MFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNK 424

  Fly   428 KKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMKYTINNLLL 487
            .......:.|||:|||||||:||..:.:.:.|..::.||.|:...:|.:|:|.....|||
Human   425 DNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLL 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	CYP6-like	67..494	CDD:410679	136/438 (31%)
CYP3A7-CYP3A51P	NP_001243426.2	CYP3A	67..492	CDD:410743	139/443 (31%)