DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a23 and CYP72A15

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001325567.1	Gene:	CYP72A15 / 820697	AraportID:	AT3G14690	Length:	547	Species:	Arabidopsis thaliana

Alignment Length:	548	Identity:	141/548 - (25%)
Similarity:	242/548 - (44%)	Gaps:	91/548 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SLLLTLIALLVSLLL--------FMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMIFRD 58
            |:.::::..:||..:        |..:....|.:|:|:......|:.|::     |::..|:...
plant    42 SVTISVVLAVVSWWIWRTLQWVWFKPKMLEHYLRRQGLAGTPYTPLVGDL-----KKNFTMLSEA 101

  Fly    59 YYTKYK-------RSV-YPFAGF------YF-FFTRSAVIT--DLELVKRVLIKDFNHFENRGIF 106
            .....|       |.| ||...|      || :|.....||  |.|.:|.|..|.:: |:....|
plant   102 RSKPLKLTDDISPRVVPYPLQMFKTYGRTYFTWFGPIPTITIMDPEQIKEVFNKVYD-FQKPHTF 165

  Fly   107 YNEIDDPLSAT----LFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIVK-----VGEEMEKIFSA 162
                  ||:..    |.:.:|.||...|..:.|.|...|:|||.|...:     || |.:::.|.
plant   166 ------PLATIIAKGLANYDGDKWAKHRRIINPAFHIEKIKNMVPAFHQSCREVVG-EWDQLVSD 223

  Fly   163 KTTTGEGQVLEIVDL---VARYTADVIGNCAFGLNCN------SLQNPNAEFVTIGKRAIIERRY 218
            |.::.|      ||:   :...|||||...|||.:..      .||...|:.:....|......|
plant   224 KGSSCE------VDVWPGLVSMTADVISRTAFGSSYKEGQRIFELQAELAQLIIQAFRKAFIPGY 282

  Fly   219 GGLLDFLIFGFPKLSRRLRLKLNVQDVEDFYTSIVRNTIDYRLRTNE----KRHDFMDSLIEMYE 279
            ..|        |..|.| |:|...::::    .|:|..::.|||..|    ...|.:..|:|...
plant   283 SYL--------PTKSNR-RMKAAAREIQ----VILRGIVNKRLRAREAGEAPSDDLLGILLESNL 334

  Fly   280 KEQAGNTEDGLSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNN 344
            ::..||   |:|..:::.:..:|:.||.||:|..:.:.:..|:..||.|.:.|.|:..|..  :.
plant   335 RQTEGN---GMSTEDLMEECKLFYFAGQETTSVLLVWTMVLLSQHQDWQARAREEVKQVFG--DK 394

  Fly   345 EFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPE 409
            |...||:.::|.:..::.|.||.||.:..|||....:....|  ..:..|..:.:|.|.:.:|.|
plant   395 EPDAEGLNQLKVMTMILYEVLRLYPPVTQLTRAIHKELKLGD--LTLPGGVQISLPILLVQHDIE 457

  Fly   410 IY-PEPEKFKPERFTDE-AIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVST 472
            :: .:..:|.|:||.|. :.|.:...::.||..|||.|||..|.|::|.:.:|.::|.:.|.:|
plant   458 LWGNDAAEFNPDRFKDGLSKATKSQVSFFPFAWGPRICIGQNFALLEAKMAMALILRRFSFEIS- 521

  Fly   473 ETQIPMKFVVKSILLSAENGIHLKVEKL 500
            .:.:...:.|  |.:..:.|..|.:.||
plant   522 PSYVHAPYTV--ITIHPQFGAQLIMHKL 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	131/499 (26%)
CYP72A15	NP_001325567.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810