DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a23 and CYP76C3

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_182082.2	Gene:	CYP76C3 / 819166	AraportID:	AT2G45580	Length:	515	Species:	Arabidopsis thaliana

Alignment Length:	560	Identity:	132/560 - (23%)
Similarity:	225/560 - (40%)	Gaps:	124/560 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLL----LTLIALLVSLLLFMARRRHGYWQRRG-----IPHDVP-HPIYGNMKDWPKKRHIAMI 55
            :||:    |.|..||.....|.|..:    .||.     :|...| .|:.||:.......|.::
plant     3 LSLIQGMSLPLYFLLTLFFFFFATAK----TRRSSSTGTLPPGPPILPLVGNIFQLGFNPHRSL- 62

  Fly    56 FRDYYTKYKRSVYPFAGFYFFFTRSAVITDLELVKRVL---------------IKDFNHFENRGI 105
                 ..:.::..|..........:.||:..|..|..|               ::.|:|.::..:
plant    63 -----AAFSKTYGPIMSLKLGRLTAVVISSPEAAKEALRTHDHVMSARTFNDALRAFDHHKHSIV 122

  Fly   106 FYNEIDDPLSATLFSIEGQKWRHLRHKLT---------PTFTSGKMKNMFPIIVKVGEEMEKIFS 161
            :.     |.||        :||.|:..:|         ....|.:|:.:..::..|.|..|:
plant   123 WI-----PPSA--------RWRFLKKTITKYLLSPQNLDAIQSLRMRKVEELVSLVNEFRER--- 171

  Fly   162 AKTTTGEGQVLEIVDLVARYTADVIGNCAFGLNCNSLQNPNA--EFVTIGKRAIIERRYGGLLDF 224
                 ||...|.....|..:  ::|.|..|.::..:..:.::  ||    ...::.     |.|
plant   172 -----GEAIDLARASFVTSF--NIISNALFSVDLATYDSNSSSYEF----HNTVVH-----LTD- 219

  Fly   225 LIFGFPKLS------RRLRL----KLNVQDVEDFYTSIVRNTIDYRL-----RTNEKRH-----D 269
             |.|.|.:.      |.|.|    |..|..:|..: .:.:..||.||     ||.::..     |
plant   220 -IAGIPNVGDYFQYMRFLDLQGTRKKAVLCIEKLF-RVFQEFIDARLAKRFSRTEKEPKEASSID 282

  Fly   270 FMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAE 334
            .:|||:::.::.:|     .|:.|::.......||||.:|:|:||.:|:.||....:...:.::|
plant   283 MLDSLLDLTQQNEA-----ELTMNDLKHLLLDVFVAGTDTNSSTMEWAMTELFRSTEKMVKAQSE 342

  Fly   335 INNVLSKHNNEFTYEG-IKEMKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVV 398
            |..|:.:  |.|..|. |..:.||:.:|.||||.:|....:.|.:::|.  :...:.:.|.|.||
plant   343 IRQVIGQ--NGFVQESDIPSLPYLQAIVKETLRLHPAAPLIPRKSESDV--QIMGFLVPKNTQVV 403

  Fly   399 IPALGIHYDPEIYPEPEKFKPERF----TDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGL 459
            :....|..|..::..|.||:||||    ||  :..| ....:|||.|.|.|.|:...|....:.|
plant   404 VNVWAIGRDASVWENPMKFEPERFLLRETD--VKGR-DFELIPFGSGRRMCPGISMALKTMHMVL 465

  Fly   460 AYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKVEK 499
            |.|:  |.|....:..:    |..:|.:|...|:.|...|
plant   466 ASLL--YSFDWKLQNGV----VPGNIDMSETFGLTLHKAK 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	119/510 (23%)
CYP76C3	NP_182082.2	p450	48..506	CDD:299894	119/511 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010