DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and Cyp4x1

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001003947.1	Gene:	Cyp4x1 / 81906	MGIID:	1932403	Length:	507	Species:	Mus musculus

Alignment Length:	528	Identity:	144/528 - (27%)
Similarity:	233/528 - (44%)	Gaps:	106/528 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 WPKKRHIAMIF----------RDYYTKYK--RSVYPF--------AGFYFFFTRSAVITDLELVK 90
            |.:..|:|::|          :.|..:.:  |.:.||        .|...|.....:.|..|:||
Mouse    10 WARPLHLALVFCLALVLMQAMKLYLRRQRLLRDLSPFPGPPAHWLLGHQKFLQEDNMETLDEIVK 74

  Fly    91 R------VLIKDFNHFENRGIFYNEIDDP------LSAT------------------LFSIEGQK 125
            :      ..:..|..|     ||  |.||      ||.|                  |.:::|.:
Mouse    75 KHPCAFPCWVGPFQAF-----FY--IYDPDYAKIFLSRTDPKMQYLHQLLTPCIGRGLLNLDGPR 132

  Fly   126 WRHLRHKLTPTFTSGKMKNMFPII------VKVG-EEMEKIFSAKTTTGEGQVLEIVDLVARYTA 183
            |...|..|||.|....:|   |.:      |||. ::.||:::.:.||.|  |.|.::|:   |.
Mouse   133 WFQHRCLLTPAFHQDILK---PCVDTMAHSVKVMLDKWEKMWTTQETTIE--VFEHINLM---TL 189

  Fly   184 DVIGNCAFGLNCNSLQNPNAEF---VTIGKRAIIERRYGGLLDF-----LIFGFPKLSRRLRLKL 240
            |:|..||||...|...|...|.   .|.....||..|   |.:|     :||   |||.:.....
Mouse   190 DIIMKCAFGQETNCQINGTYESYVKATFELGEIISSR---LYNFWHHHDIIF---KLSPKGHCFQ 248

  Fly   241 NVQDVEDFYTSIVRNTIDYRLRTNEKRHD------FMDSLIEMYEKEQAGNTEDGLSFN--EILA 297
            .:..|...||..:.......|:...|:.|      |:|.::       :...||..:|:  ::.|
Mouse   249 ELGKVIHQYTEKIIQDRKKILKNQVKQDDTQTSQIFLDIVL-------SAQAEDERAFSDADLRA 306

  Fly   298 QAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVM 362
            :...|..||.:.|:.::.:.||.|||:.:.||:.|.||.::|. ..:..|:|.:.||.|....:.
Mouse   307 EVNTFMWAGHDASAASISWLLYCLALNPEHQDRCRTEIRSILG-DGSSITWEQLDEMSYTTMCIK 370

  Fly   363 ETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAI 427
            ||||..|.:..::|......:..| .:.:..|.|||:...|:|::|.::.:|:.|.|.|||.|..
Mouse   371 ETLRLIPPVPSISRELSKPLTLPD-GHSLPAGMTVVLSIWGLHHNPAVWNDPKVFDPLRFTKENS 434

  Fly   428 AARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENG 492
            ..|..|.:|||..|||||||.:|.:::..|.:|.::  ..|.|:.:...|..|...:: |..::|
Mouse   435 DQRHPCAFLPFSSGPRNCIGQQFAMLELKVAIALIL--LHFQVAPDLTRPPAFSSHTV-LRPKHG 496

  Fly   493 IHLKVEKL 500
            |:|.::||
Mouse   497 IYLHLKKL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	141/521 (27%)
Cyp4x1	NP_001003947.1	p450	47..499	CDD:278495	133/484 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910