DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and cyp46a1.3

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001038763.1	Gene:	cyp46a1.3 / 692332	ZFINID:	ZDB-GENE-060519-40	Length:	491	Species:	Danio rerio

Alignment Length:	499	Identity:	126/499 - (25%)
Similarity:	220/499 - (44%)	Gaps:	83/499 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLLTLIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNM----KDWPKKRHIAMIFRDYYTKY 63
            ||..:..:.::..|::.:....|....|.|.|  :.:.|::    :....:||:..:...:..||
Zfish    13 LLSAVFVVFLAYCLYIHQVHQKYDHIPGPPRD--NFLLGHIPTINRVTKSERHMNDLLLIWAEKY 75

  Fly    64 KRSVYPFAGFYFFFTRSAVITDL---ELVKRVL-----IKD-------FNHFENRGIFYNEIDDP 113
             ..||....|::      ||.::   |..|.::     :||       |..|..|.:.|..:
Zfish    76 -GPVYRLNSFHY------VIINVHCPEATKTIMMSPKYLKDPFIYKRLFGLFGKRFLGYGLV--- 130

  Fly   114 LSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIVKVGE----EMEKIFSAKTTTGEGQVLEI 174
             :||...|    |...|..:.|.|:|..::.:.....::.|    ::|::...||..    |:.
Zfish   131 -TATDHDI----WYRQRRIMDPAFSSSYLRGLISTFNEMSERLMDKLEEMAINKTPA----VMH- 185

  Fly   175 VDLVARYTADVIGNCAFGLNCNSLQNPNAEFVTIGKRAIIERRYGGLLD----FLIFGFPKLSRR 235
             |||...|.|:|...|||::.|..:..:..|    ::||.:...|.:||    |..| |||..:.
Zfish   186 -DLVNCVTLDIICKVAFGVDLNLFKQTDNPF----QQAIEQCLQGMVLDLRDPFCKF-FPKNWKA 244

  Fly   236 LRLKLNVQDVEDFYTSIVRNTIDYRLRTNEKR---------HDFMDSLIEMYEKEQAGNTEDGLS 291
                  :|:.:. .|.::|.|.:..:: |.|.         :|.:..:::..::|:..||:|
Zfish   245 ------IQETKG-ATVLLRKTGEQWIQ-NRKTAVEIGEDVPNDILTQILKTAKEEKVNNTKD--- 298

  Fly   292 FNEILAQAFI-FFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMK 355
             :|.:...|: ||:||.||::..:.||:.||....:|..:.:||::.||.. ..:.:||.:.:..
Zfish   299 -HEQMLDNFVTFFIAGQETTANQLSFAIMELGRHPEIYKRAKAEVDEVLGT-KRDISYEDLGKFT 361

  Fly   356 YLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPE 420
            ||.||:.||||.||......|....|......|  |..|.:|:..:.......:.:.:|.||.||
Zfish   362 YLSQVLKETLRLYPTAPGTNRWLHEDMVINGIK--IPGGISVIFSSYVAQRLEKHFKDPLKFDPE 424

  Fly   421 RFTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVG-LAYLI 463
            ||  ...|.:|...:.||..|||:|:|..|.......| ||.|:
Zfish   425 RF--NVNAPKPYYCYYPFSLGPRSCLGQVFSQATPAEGALAQLL 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	119/466 (26%)
cyp46a1.3	NP_001038763.1	p450	39..452	CDD:278495	117/457 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910