Protein Alignment Cyp6a23 and TBXAS1

DIOPT Version :9

• Sequence 1: NP_611000.2
• Gene: Cyp6a23 / 36661
• FlyBaseID: FBgn0033978
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 600
• Identity: 157/600 - (26%)
• Similarity: 255/600 - (42%)
• Gaps: 145/600 - (24%)

  Fly     5 LTLIALLVSLLLFMARRRHGYW---------QRRGIPHDVPHPIYGNMKDWPKKRHIAMIFRDYY 60
            :..:||.|:||..:.      |         ::.|:.|..|.|..||:          ..||..:
Human    15 MVTVALSVALLALLK------WYSTSAFSRLEKLGLRHPKPSPFIGNL----------TFFRQGF 63

  Fly    61 TKYK---RSVY-PFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENR---GIFYNEIDDPLSATL 118
            .:.:   |.:| |..|:|.......||::.:::|:||:::|::|.||   |:.:..:.|   :.|
Human    64 WESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVAD---SVL 125

  Fly   119 FSIEGQKWRHLRHKLTPTFTSGKMKN--------------------------------------- 144
            | :..::|..:|..|...|:..|:..
Human   126 F-LRDKRWEEVRGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLH 189

  Fly   145 -------MFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNCAFGLNCNSLQNPN 202
                   |.|:|.:..:.:  :...|.....|...:|......||.||:.:.|||...:|.|.|.
Human   190 YATLPFCMVPLISQACDLL--LAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPE 252

  Fly   203 AEFVTIGKRAIIERRYGGLLDF--------LIFGFPK----LSRRLRLKLNVQDVEDFYTSIVRN 255
            ..||...||         ..:|        |:..||.    |:|.|..| |..::..|:..::||
Human   253 DPFVKHCKR---------FFEFCIPRPILVLLLSFPSIMVPLARILPNK-NRDELNGFFNKLIRN 307

  Fly   256 TIDYR--LRTNEKRHDFMDSLIEMYEKEQAGNTED----------------------------GL 290
            .|..|  ....|:|.||:..:::..........:|                            .|
Human   308 VIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPL 372

  Fly   291 SFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKH-NNEF--TYEGIK 352
            :.:||:.|||||.:||:|..:.|:.||.|.||.:.|.|::|..|::....|| ..||  ..||
Human   373 TVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG-- 435

  Fly   353 EMKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKF 417
             :.||:.|:.||||.||.....||....|......:  |..|..:.:....:|:|||.:|.||.|
Human   436 -LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWPSPETF 497

  Fly   418 KPERFTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVV 482
            .|||||.||.......|:||||.|||:|:|:|.||::..:.|.:::..::|....|||:|::...
Human   498 NPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLES 562

  Fly   483 KSILLSAENGIHLKV 497
            || .|..:||:::|:
Human   563 KS-ALGPKNGVYIKI 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	148/556 (27%)
TBXAS1	NP_001159725.2	p450	47..576	CDD:306555	148/560 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130979
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.850