DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and Cyp4f14

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001191262.1	Gene:	Cyp4f14 / 64385	MGIID:	1927669	Length:	524	Species:	Mus musculus

Alignment Length:	545	Identity:	140/545 - (25%)
Similarity:	240/545 - (44%)	Gaps:	93/545 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLLTLIALLVSLL--LFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKR----HIAMIFRDYYT 61
            |||....:|..:|  ::.|.|.:.:.      |..|.|        ||:.    |:.|:     |
Mouse    23 LLLGASWILARILIQIYAAYRNYRHL------HGFPQP--------PKRNWLMGHVGMV-----T 68

  Fly    62 KYKRSV---------YPFAGFYFFFTRSAVITDL---ELVKRVL-------IKDFNHFENRGIFY 107
            ..::.:         || .||..:......:..|   ::|:.:|       :||.       |||
Mouse    69 PTEQGLKELTRLVGTYP-QGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDV-------IFY 125

  Fly   108 NEIDDPLSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAK----TTTGE 168
            :.:...|...|....|.||...|..|||.|..    |:....||:..:...|..||    .:.|.
Mouse   126 SILKPWLGDGLLVSAGDKWSRHRRMLTPAFHF----NILKPYVKIFNDSTNIMHAKWQRLISDGS 186

  Fly   169 GQVLEIVDLVARYTADVIGNCAFGLNCNSLQNPNAEFVT--IGKRAIIERRYGGLLDF--LIFGF 229
            .: |::.:.|:..|.|.:..|.|..:.| .|..::|::.  :...|::.:|:...|.|  |::..
Mouse   187 AR-LDMFEHVSLMTLDSLQKCVFSFDSN-CQEKSSEYIAAILELSALVAKRHQQPLMFMDLLYNL 249

  Fly   230 PKLSRRLRLKLNVQDVEDFYTSIVRNT--------IDYRLRTNEKRH--DFMDSLIEMYEKEQAG 284
            .....|.|...||  |.:|..:::|..        :|..|::..|..  ||:|.|:       ..
Mouse   250 TPDGMRFRKACNV--VHEFTDAVIRERHRTLPDQGLDDFLKSKAKSKTLDFIDVLL-------LS 305

  Fly   285 NTEDG--LSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVL-SKHNNEF 346
            ..|||  ||..:|.|:|..|...|.:|:::.:.:.||.||...:.|::.|.|:..:| .:...|.
Mouse   306 KDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVQELLRGREPEEI 370

  Fly   347 TYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIY 411
            .::.:.::.:|...:.|:||.:|.:..::|....|....|.: .|.||...:|...|||::|.::
Mouse   371 EWDDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDILLPDGR-TIPKGIICLISIFGIHHNPSVW 434

  Fly   412 PEPEKFKPERFTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQI 476
            |:||.:.|.||..|.|.......::||..|||||||..|.:.:..|.||..:  .:|.:..:.:.
Mouse   435 PDPEVYDPFRFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTL--LRFRLLPDDKE 497

  Fly   477 PMKFVVKSILLSAENGIHLKVEKLS 501
            |.:  ...::|.||.|:.|:||.||
Mouse   498 PRR--QPELILRAEGGLWLRVEPLS 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	127/502 (25%)
Cyp4f14	NP_001191262.1	p450	52..511	CDD:365848	126/499 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910