DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and Cyp4f40

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	XP_006524820.1	Gene:	Cyp4f40 / 631304	MGIID:	3645508	Length:	551	Species:	Mus musculus

Alignment Length:	561	Identity:	143/561 - (25%)
Similarity:	231/561 - (41%)	Gaps:	114/561 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLLLTLIALLVSLLLFMAR-------------RRHGYWQRRGIPHDVPHPIYGNMKDWPKKR-- 50
            ||....|:..||.:..|:||             |..|:          |.|        |||.
Mouse    41 MSASPWLLFFLVGISWFLARFLTQLYTLYAKCQRLCGF----------PQP--------PKKNWF 87

  Fly    51 --HIAMI---------FRDYYTKYKRSVYPFAGFYFFFTRSAVITDL------ELVKRVLIKDFN 98
              |:.|.         ..:..|.|.:.         |.|....|..|      ::::.||.....
Mouse    88 WGHLGMSPPTEEGMKQVTELVTTYPQG---------FMTWLGPIVPLITLCHPDIIRSVLSASAA 143

  Fly    99 HFENRGIFYNEIDDPLSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAK 163
            ......|||:.:...|...|....|.||...|..|||.|..    |:....||:..:...|..||
Mouse   144 VAPKDDIFYSFLKPWLGDGLLVSAGDKWNRHRRMLTPAFHF----NILKPYVKIFNDSTNIMHAK 204

  Fly   164 ---TTTGEGQVLEIVDLVARYTADVIGNCAFGLNCNSLQNPNAEFVTIGKRAIIE------RRYG 219
               ..:|....|.:.:.::..|.|.:..|.|..|.|..:.| ::::.    ||:|      :|..
Mouse   205 WLRLASGGSTRLNMFENISLMTLDTLQKCVFSFNSNCQEKP-SQYIA----AILELSTLAVKRNE 264

  Fly   220 GLL---DFLIFGFP---KLSRRLRLKLNVQDVEDFYTSIV---RNTI-------DYRLRTNEKRH 268
            .||   |.|....|   :..:..||      |.||..:::   |.|:       ..:.:...|..
Mouse   265 QLLMHVDLLYRLTPDGMRFYKACRL------VHDFTDAVIQERRRTLLKHGGDDIIKAKAKSKTL 323

  Fly   269 DFMDSLIEMYEKEQAGNTEDG--LSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQL 331
            ||:|.|:       ....|||  ||..:|.|:|..|...|.:|:::.:.:.||.||...:.|::.
Mouse   324 DFIDVLL-------LTKDEDGKELSDEDIRAEADTFMFRGHDTTASGLSWILYNLARHPEHQERC 381

  Fly   332 RAEINNVL-SKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGT 395
            |.|:..:| .:...|..::.:.::.:|...:.|:||.:|.:..::|....|.|..|.: .|.||.
Mouse   382 RQEVQELLRDRDPKEIEWDDLAQLPFLTMCIKESLRLHPPVTMVSRCCTQDISLPDGR-IIPKGV 445

  Fly   396 TVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLA 460
            ..:|...|.|::|.::.:||.:.|.||..|.|.||...:::||..|||||||..|.:.:..|.||
Mouse   446 ICIINIFGTHHNPTVWRDPEVYDPFRFDPENIQARSPLSFIPFSAGPRNCIGQTFAMSEMKVALA 510

  Fly   461 YLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKVEKLS 501
            ..:  .:|.:..:.:.|.:  ...::|.||.|:.|:||.||
Mouse   511 LTL--LRFRILPDDKEPRR--KPELILRAEGGLWLRVEPLS 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	128/505 (25%)
Cyp4f40	XP_006524820.1	p450	79..542	CDD:365848	128/506 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910