DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and Cyp3a25

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_062766.2	Gene:	Cyp3a25 / 56388	MGIID:	1930638	Length:	503	Species:	Mus musculus

Alignment Length:	517	Identity:	171/517 - (33%)
Similarity:	268/517 - (51%)	Gaps:	49/517 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TLIALLVSLLLF--MARRRHGYWQRRGIPHDVPHPIYG---NMKD--WPKKRHIAMIFRDYYTKY 63
            |.:.|:.||:||  .....||.:::.|||...|.|:.|   |..|  |       ....|.|.||
Mouse    11 TWVLLVTSLVLFYIYGTYSHGLFKKLGIPGPKPLPLLGTIFNYYDGMW-------KFDEDCYKKY 68

  Fly    64 KRSVYPFAGFYFFFTRSAVITDLELVKRVLIKD-FNHFENRGIFYNEIDDPLSATLFSIEGQKWR 127
            .:    ..|||........|.|.|::|.||:|: ::.|.||. |:..:.....|...| |.::|:
Mouse    69 GK----IWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRR-FFGPVGFMKKAITIS-EDEEWK 127

  Fly   128 HLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNCAFG 192
            .||..|:|||||||:|.||||:.:.|:.:  :.:.:....:|:.:.:.|:...|:.|||...:||
Mouse   128 RLRTLLSPTFTSGKLKEMFPIMRQYGDIL--VRNLRREEEKGEPISMKDIFGAYSMDVITGTSFG 190

  Fly   193 LNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFG--------FPKLS---RRLRLKLNVQDVE 246
            :|.:||.||...||...|:         :|.|.||.        ||.|:   ..|...:..:|..
Mouse   191 VNVDSLNNPQDPFVQKAKK---------ILKFKIFDPFLLSIILFPFLTPIYEMLNFSIFPRDSM 246

  Fly   247 DFYTSIVRNTIDYRLRTNEK-RHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFETS 310
            :|:...|:.....||.:|:| |.||:..::.. :..:...::..||..|:.|||.||...|::.:
Mouse   247 NFFKKFVKRMKKERLASNQKNRVDFLQLMMNT-QNSKGQESQKALSDLEMAAQAVIFIFGGYDAT 310

  Fly   311 STTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLT 375
            ||::...:||||...|:|.:|:.||:..| .:....||:.:.:|:||:.||.|:||.||:...|.
Mouse   311 STSISLIMYELATHPDVQKKLQDEIDRTL-PNKAPVTYDALMDMEYLDMVVNESLRLYPIAIRLE 374

  Fly   376 RMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGE 440
            |:::.|.  |....||.|||.|:||...:|.:||.:|||::|.||||:.|.........::|||.
Mouse   375 RVSKKDV--EINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSKENKGNIDPYIYMPFGN 437

  Fly   441 GPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKVEKLSK 502
            |||||||:||.|:...:.:..:::.:......|||||:| :.:..:...|..|.|||....|
Mouse   438 GPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQIPLK-ISREPIFQPEKPIILKVVSRDK 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	156/476 (33%)
Cyp3a25	NP_062766.2	p450	39..493	CDD:278495	158/482 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720