Protein Alignment Cyp6a23 and Cyp3a25

DIOPT Version :10

• Sequence 1: NP_611000.2
• Gene: Cyp6a23 / 36661
• FlyBaseID: FBgn0033978
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_062766.2
• Gene: Cyp3a25 / 56388
• MGIID: 1930638
• Length: 503
• Species: Mus musculus
• Alignment Length: 517
• Identity: 171/517 - (33%)
• Similarity: 268/517 - (51%)
• Gaps: 49/517 - (9%)

  Fly     6 TLIALLVSLLLF--MARRRHGYWQRRGIPHDVPHPIYG---NMKD--WPKKRHIAMIFRDYYTKY 63
            |.:.|:.||:||  .....||.:::.|||...|.|:.|   |..|  |       ....|.|.||
Mouse    11 TWVLLVTSLVLFYIYGTYSHGLFKKLGIPGPKPLPLLGTIFNYYDGMW-------KFDEDCYKKY 68

  Fly    64 KRSVYPFAGFYFFFTRSAVITDLELVKRVLIKD-FNHFENRGIFYNEIDDPLSATLFSIEGQKWR 127
            .:    ..|||........|.|.|::|.||:|: ::.|.||. |:..:.....|...| |.::|:
Mouse    69 GK----IWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRR-FFGPVGFMKKAITIS-EDEEWK 127

  Fly   128 HLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNCAFG 192
            .||..|:|||||||:|.||||:.:.|:.:  :.:.:....:|:.:.:.|:...|:.|||...:||
Mouse   128 RLRTLLSPTFTSGKLKEMFPIMRQYGDIL--VRNLRREEEKGEPISMKDIFGAYSMDVITGTSFG 190

  Fly   193 LNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFG--------FPKLS---RRLRLKLNVQDVE 246
            :|.:||.||...||...|:         :|.|.||.        ||.|:   ..|...:..:|..
Mouse   191 VNVDSLNNPQDPFVQKAKK---------ILKFKIFDPFLLSIILFPFLTPIYEMLNFSIFPRDSM 246

  Fly   247 DFYTSIVRNTIDYRLRTNEK-RHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFETS 310
            :|:...|:.....||.:|:| |.||:..::.. :..:...::..||..|:.|||.||...|::.:
Mouse   247 NFFKKFVKRMKKERLASNQKNRVDFLQLMMNT-QNSKGQESQKALSDLEMAAQAVIFIFGGYDAT 310

  Fly   311 STTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLT 375
            ||::...:||||...|:|.:|:.||:..| .:....||:.:.:|:||:.||.|:||.||:...|.
Mouse   311 STSISLIMYELATHPDVQKKLQDEIDRTL-PNKAPVTYDALMDMEYLDMVVNESLRLYPIAIRLE 374

  Fly   376 RMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGE 440
            |:::.|.  |....||.|||.|:||...:|.:||.:|||::|.||||:.|.........::|||.
Mouse   375 RVSKKDV--EINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSKENKGNIDPYIYMPFGN 437

  Fly   441 GPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKVEKLSK 502
            |||||||:||.|:...:.:..:::.:......|||||:| :.:..:...|..|.|||....|
Mouse   438 GPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQIPLK-ISREPIFQPEKPIILKVVSRDK 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	CYP6-like	68..494	CDD:410679	145/438 (33%)
Cyp3a25	NP_062766.2	CYP3A	67..492	CDD:410743	148/446 (33%)