DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and Cyp4f1

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_062569.2	Gene:	Cyp4f1 / 56266	RGDID:	70926	Length:	524	Species:	Rattus norvegicus

Alignment Length:	536	Identity:	135/536 - (25%)
Similarity:	231/536 - (43%)	Gaps:	89/536 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKR-----HIAMIFRDYYTKYKRSV-- 67
            :|..:|..:......:.:.||.|.             |.||     |:.|:     |..::.:
  Rat    30 ILAQILTQIYAAYRNFRRLRGFPQ-------------PPKRNWLMGHVGMV-----TPTEQGLKE 76

  Fly    68 -------YPFAGFYFFFTRSAVITDL---ELVKRVL-------IKDFNHFENRGIFYNEIDDPLS 115
                   || .||..:......:..|   ::|:.:|       :||.       |||..:...|.
  Rat    77 LTRLVGTYP-QGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDV-------IFYTILKPWLG 133

  Fly   116 ATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSA--KTTTGEGQV-LEIVDL 177
            ..|....|.||...|..|||.|..    |:....||:..:...|..|  |....||.. |::.:.
  Rat   134 DGLLVSAGDKWSRHRRMLTPAFHF----NILKPYVKIFNDSTNIMHAKWKRLISEGSSRLDMFEH 194

  Fly   178 VARYTADVIGNCAFGLNCNSLQNPNAEFVT--IGKRAIIERRYGGLLDF--LIFGFPKLSRRLRL 238
            |:..|.|.:..|.|..:.| .|..::|::.  :...|::.:|:...|.|  |::.......|...
  Rat   195 VSLMTLDSLQKCVFSFDSN-CQEKSSEYIAAILELSALVAKRHQQPLLFMDLLYNLTPDGMRFHK 258

  Fly   239 KLNVQDVEDFYTSIVRNT--------IDYRLRTNEKRH--DFMDSLIEMYEKEQAGNTEDG--LS 291
            ..|:  |.:|..:::|..        :|..|::..|..  ||:|.|:       ....|||  ||
  Rat   259 ACNL--VHEFTDAVIRERRRTLPDQGLDEFLKSKAKSKTLDFIDVLL-------LTKDEDGKELS 314

  Fly   292 FNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVL-SKHNNEFTYEGIKEMK 355
            ..:|.|:|..|...|.:|:::.:.:.||.||...:.|::.|.|:..:| .:...|..::.:.::.
  Rat   315 DEDIRAEADTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQELLRDRDPEEIEWDDLAQLP 379

  Fly   356 YLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPE 420
            :|...:.|:||.:|.:..::|....|....|.: .|.||...:|...|||::|.::|:||.:.|.
  Rat   380 FLTMCIKESLRLHPPVTVISRCCTQDILLPDGR-TIPKGIICLISIFGIHHNPSVWPDPEVYNPF 443

  Fly   421 RFTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSI 485
            ||..|.|.......::||..|||||||..|.:.:..|.||..:  .:|.:..:.:.|.:  ...:
  Rat   444 RFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTL--LRFRLLPDDKEPRR--QPEL 504

  Fly   486 LLSAENGIHLKVEKLS 501
            :|.||.|:.|:||.||
  Rat   505 ILRAEGGLWLRVEPLS 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	125/502 (25%)
Cyp4f1	NP_062569.2	CYP4F	74..515	CDD:410772	119/467 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910