DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and cyp4v7

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001073465.1	Gene:	cyp4v7 / 562008	ZFINID:	ZDB-GENE-061103-88	Length:	510	Species:	Danio rerio

Alignment Length:	548	Identity:	134/548 - (24%)
Similarity:	240/548 - (43%)	Gaps:	93/548 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLLLT--LIALLVSLLLFMARRRHGYW-QRRGIPHDV-PHPIYGNMKDWPKKRHIAMIFR---- 57
            :.:|.|  |:.||.|......:...|.| :.|.||... .:||.||          |:.|:
Zfish    10 LGILFTAVLLLLLASTAYNPLKNYIGKWNEMRPIPGMAGAYPIIGN----------ALQFKTNAG 64

  Fly    58 DYY------TKYKRSVYPFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENRGIFYNEIDDPLSA 116
            |::      |...|.: |.|..:.......::...|.:: |::.:..|.: :...|..:...|..
Zfish    65 DFFNQIIEGTNENRHL-PLAKVWVGPVPFLILYHAENIE-VVLSNSRHLD-KSYSYRFLHPWLGT 126

  Fly   117 TLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARY 181
            .|.:..|:|||:.|..|||||....:.:...:   :.|:.:.:........:|:.....:.:...
Zfish   127 GLLTSTGEKWRNRRKMLTPTFHFSILSDFLEV---MNEQTDILIQKMQKLEDGEPFNCFNFITLC 188

  Fly   182 TADVIGNCAFGLNCNSLQNPNAEFV-TIGKRA--IIERRYGGLL--DFLIFGFPKL------SRR 235
            ..|:|...|.|....:..|.::|:| ::.|.:  |.:|:....|  |::   :.||      ::|
Zfish   189 ALDIICETAMGKKIYAQSNADSEYVQSVYKMSDIITKRQRAPWLWPDWI---YNKLKEGKEHAKR 250

  Fly   236 LRLKLNVQDVEDFYTSIVRNTIDYRL--------RTNEKRHDFMDSLIE-MYEKEQAGNTEDGLS 291
            |::      :..|..:::|...::..        :...||..|:|.|:: .||..|.      ||
Zfish   251 LKI------LHSFTANVIRERAEFMSSEPDSDSDQGERKRQAFLDMLLKTTYENGQK------LS 303

  Fly   292 FNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKY 356
            ..:|..:...|...|.:|::.:|.:||:.:....::|..::||:..|..........|.:|:::|
Zfish   304 HEDIQEEVDTFMFEGHDTTAASMNWALHLIGSHPEVQKAVQAELQEVFGSSERHVGVEDLKKLRY 368

  Fly   357 LEQVVMETLRKYPVL----------AHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIY 411
            ||.|:.|:||.:|.:          .|:.            .:.:.||...||....:|.||..:
Zfish   369 LECVIKESLRIFPSVPLFARSICEACHIN------------GFKVPKGVNAVIIPYALHRDPRYF 421

  Fly   412 PEPEKFKPERFTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSV--STET 474
            ||||:|:||||..|....|....::||..|||||||.||.:|:..|.||.::|.:....  |.|.
Zfish   422 PEPEEFQPERFMPENSKGRHPYAYIPFSAGPRNCIGQRFAMMEEKVVLATILRHFDVEACQSREE 486

  Fly   475 QIPMKFVVKSILLSAENGIHLKVEKLSK 502
            ..|:    ..::|..|.||.:|:::.||
Zfish   487 LRPL----GELILRPEKGIWIKLQRRSK 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	120/500 (24%)
cyp4v7	NP_001073465.1	p450	44..505	CDD:278495	121/507 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820