DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a23 and cyp4v8

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001071070.1	Gene:	cyp4v8 / 558851	ZFINID:	ZDB-GENE-061103-601	Length:	513	Species:	Danio rerio

Alignment Length:	480	Identity:	120/480 - (25%)
Similarity:	210/480 - (43%)	Gaps:	41/480 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PIYGNMKDWPKKRHIAMIFRDYYTKYKRSVYPFAGFYFFFTRSAVITDLELVKRVLIKDFNHFEN 102
            |..||...:.......:....|.|:::.|  |....:.......::...|.|:.||.... |.:
Zfish    51 PFIGNALQFKSNGDFFLQLVGYTTEFQNS--PLLKIWIGPIPFLILFHAETVETVLNNPV-HID- 111

  Fly   103 RGIFYNEIDDPLSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTG 167
            :...|..:...|...|.:..|.|||..|..|||||....:.....::.:..|.:.:....:...|
Zfish   112 KAYAYQFLHPWLGTGLLTSTGDKWRRRRKMLTPTFHFSILTEFLEVMNEQAEVLIEKLEKQAGKG 176

  Fly   168 EGQVLEIVDLVARYTADVIGNCAFGLNCNSLQNPNAEFV-TIGKRA-IIERR-----YGGLLDFL 225
            .......:.|.|   .|:|...|.|....:..|.::|:| |:.:.: ||.||     |..  ||
Zfish   177 PFNCFSHITLCA---LDIICETAMGKRIYAQSNYDSEYVRTVYRMSDIITRRQRMPWYWP--DF- 235

  Fly   226 IFGFPKLSRRLRLKLNVQDVEDFYTSIVRNTIDYRLRTN---------EKRHDFMDSLIEMYEKE 281
            ::.:....|.....|.:  :..|..|::....:|.....         .||..|:|.|::..:
Zfish   236 VYNYVGEGREHNRSLKI--LHSFTESVINERAEYLSYVESDSESDQGMRKRRAFLDMLLKTKD-- 296

  Fly   282 QAGNTEDG--LSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNN 344
                 |||  |:..:|..:...|...|.:|::..|.:|::.|....::|.:.:.|:..|..:...
Zfish   297 -----EDGKMLTHKDIQEEVDTFMFEGHDTTAAAMNWAIHLLGSHPEVQRKAQQELFEVFGESER 356

  Fly   345 EFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPE 409
            ....|.:|:::|||.|:.|:||.:|.:....|....|......|  :.|||.:|:....:|.||.
Zfish   357 PVNTEDLKKLRYLECVIKESLRLFPSVPFFARTICDDTQINGFK--VPKGTNIVVITYALHRDPR 419

  Fly   410 IYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTET 474
            .:|:||:|:||||..|....|....::||..|.|||||.||.:|:..|.|||::|.:.. |:.:.
Zfish   420 FFPDPEEFRPERFLPENCVGRHPYAYIPFSAGLRNCIGQRFAIMEEKVILAYILRYFNI-VACQK 483

  Fly   475 QIPMKFVVKSILLSAENGIHLKVEK 499
            :..:: .:..::|..|.||.:.:|:
Zfish   484 REELR-PLGELVLRPEQGIWITLER 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	119/474 (25%)
cyp4v8	NP_001071070.1	p450	44..501	CDD:278495	117/472 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820