DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and cyp3c4

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001071016.1	Gene:	cyp3c4 / 558541	ZFINID:	ZDB-GENE-060929-96	Length:	507	Species:	Danio rerio

Alignment Length:	493	Identity:	145/493 - (29%)
Similarity:	257/493 - (52%)	Gaps:	24/493 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLLLTLIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMIFRDYYTKYKR 65
            :|:..||:.|:::||.......|.::.:.|||...|.|..|.:..:.|  .:.....:...||.:
Zfish     7 LSVTWTLVVLVITLLFIYGVWPHRFFIKLGIPGPRPWPFVGTLLSYAK--GLCNFDMECAKKYGK 69

  Fly    66 SVYPFAGFYFFFTRSAVITDLELVKRVLIKD-FNHFENRGIFYNEIDDPLSATLFSIEGQKWRHL 129
             |:   |.|.......::.|||::|.||:|: :::|.||......:..|.|..:..::.::|:.:
Zfish    70 -VW---GIYDGRLPILMVADLEVIKVVLVKECYSNFINRRKRTTGLAGPFSDGIIMVKDERWKRM 130

  Fly   130 RHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNCAFGLN 194
            |..|:|.||||::|.:|||.:...:...|....|...   |.::|.::||.|:.|||.:.:|.::
Zfish   131 RSTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKKDPE---QPVKIKEVVAPYSLDVITSSSFSVD 192

  Fly   195 CNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFGFPKLS---RRLRLKLNVQDVEDFYTSIVRNT 256
            .:|:.||...||...|:.|....:..|| .||..||.|:   :::.:.|..:...||:.|:::..
Zfish   193 IDSINNPEDPFVINVKKFIQFNMFNPLL-LLILLFPSLAIPLKKMGVTLFSKSAMDFFYSVLKKI 256

  Fly   257 IDYRLRTNEKRHDFMDSLI-------EMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFETSSTTM 314
            .|...:.:|.|.||:..::       ::.:.:.:.....||:.:|||:|:.:|.:.|:||:|||:
Zfish   257 KDDHNKESEGRVDFLKLMLQNQIPDDQIQDSDTSEQPAKGLTDHEILSQSLVFILGGYETTSTTL 321

  Fly   315 GFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQ 379
            .|.||.||.:.|..::|..||:..... :...||:.:..|.|||..:.|::|..|....|.|..:
Zfish   322 TFLLYNLATNPDCLEKLVEEIDKNFPL-DTPITYDALMRMDYLEMAINESMRLLPTAPRLERSAK 385

  Fly   380 TDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPRN 444
            .......  ..|.:||.|.||...:.:||:|:..|.:|:||||:.|..:......::|||.||||
Zfish   386 KTVVING--LTIPEGTLVGIPTYVLSHDPDIWESPGEFRPERFSPENKSEFLQYAFIPFGLGPRN 448

  Fly   445 CIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVV 482
            |||:|:.:|...:.:..|::.:......|||||::..|
Zfish   449 CIGMRYAVMIMKLFVVKLLQNFSVETCKETQIPLEMNV 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	135/458 (29%)
cyp3c4	NP_001071016.1	p450	38..485	CDD:278495	135/459 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm6472
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.720