Protein Alignment Cyp6a23 and Cyp4a1

DIOPT Version :10

• Sequence 1: NP_611000.2
• Gene: Cyp6a23 / 36661
• FlyBaseID: FBgn0033978
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_787031.1
• Gene: Cyp4a1 / 50549
• RGDID: 68945
• Length: 509
• Species: Rattus norvegicus
• Alignment Length: 550
• Identity: 127/550 - (23%)
• Similarity: 238/550 - (43%)
• Gaps: 119/550 - (21%)

  Fly     8 IALLVSLLLFMARRRHGYWQRRGI-------PHDVPHPIYGNMKDWPKKRHIAMIF---RDYYTK 62
            :|.::.|||.:.:....|.||:.:       |....|..:|: |.:...:.:..|.   .::.:.
  Rat    21 VASVLGLLLLLVKAVQFYLQRQWLLKAFQQFPSPPFHWFFGH-KQFQGDKELQQIMTCVENFPSA 84

  Fly    63 YKRSVYPFAGFYFFFTRS-AVITDLELVKRVLIKDFNHFENRGIFYNEIDDPLSATLFSIEGQKW 126
            :.|        :|:.::: .::.|.:.:|.:|.:  :..:..|: |..:...:...|..:.||.|
  Rat    85 FPR--------WFWGSKAYLIVYDPDYMKVILGR--SDPKANGV-YRLLAPWIGYGLLLLNGQPW 138

  Fly   127 RHLRHKLTPTF----TSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIG 187
            ...|..|||.|    ....:|||...|..:.::.|::      .|:...:||...::..|.|.:.
  Rat   139 FQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWEQL------AGQDSSIEIFQHISLMTLDTVM 197

  Fly   188 NCAFGLNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFGFPKLSRRLRLKLNVQDVEDFYTSI 252
            .|||..| .|:|              ::..|...:.                 .:.::.|.:.|.
  Rat   198 KCAFSHN-GSVQ--------------VDGNYKSYIQ-----------------AIGNLNDLFHSR 230

  Fly   253 VRN------TIDYRLRTN--------EKRHDFMDSLIEMYEKEQ---AGNTE------------- 287
            |||      || |...:|        :..||..|.:|:: .|:|   ||..|
  Rat   231 VRNIFHQNDTI-YNFSSNGHLFNRACQLAHDHTDGVIKL-RKDQLQNAGELEKVKKKRRLDFLDI 293

  Fly   288 ---------DGLSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHN 343
                     |.||..::.|:...|...|.:|:::.:.:..|.||...:.|.:.|.|:.:||. ..
  Rat   294 LLLARMENGDSLSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPEHQQRCREEVQSVLG-DG 357

  Fly   344 NEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDP 408
            :..|::.:.::.|....:.|.||.||.:..:.|...|..:..|.: .:.||..|.:...|:|::|
  Rat   358 SSITWDHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGR-SLPKGIQVTLSIYGLHHNP 421

  Fly   409 EIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPRNCIGLRFGL--MQACVGLAYLIRGYKFSVS 471
            :::|.||.|.|.||..:  :.|.|.::|||..|.|||||.:|.:  |:..|.|..|    :|.:.
  Rat   422 KVWPNPEVFDPSRFAPD--SPRHSHSFLPFSGGARNCIGKQFAMSEMKVIVALTLL----RFELL 480

  Fly   472 TE-TQIPMKFVVKSILLSAENGIHLKVEKL 500
            .: |::|:.  :..::|.::|||:|.::||
  Rat   481 PDPTKVPIP--LPRLVLKSKNGIYLYLKKL 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	CYP6-like	68..494	CDD:410679	110/472 (23%)
Cyp4a1	NP_787031.1	CYP4B-like	71..504	CDD:410771	113/493 (23%)