DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and Cyp4f40

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	XP_038935701.1	Gene:	Cyp4f40 / 503122	RGDID:	1559596	Length:	530	Species:	Rattus norvegicus

Alignment Length:	445	Identity:	119/445 - (26%)
Similarity:	202/445 - (45%)	Gaps:	52/445 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 ELVKRVLIKDFNHFENRGIFYNEIDDPLSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIVK 151
            ::::.||..........||||:.:...|...|......||...|..|||.|..    |:....||
  Rat   105 DIIRSVLSASAAVAPKDGIFYSFLKPWLGDGLLVSASDKWSRHRSMLTPAFHF----NILKPYVK 165

  Fly   152 VGEEMEKIFSAK---TTTGEGQVLEIVDLVARYTADVIGNCAFGLNCNSLQNPNAEFVT--IGKR 211
            :..:...|..||   ..:|....|::.:.::..|.|.:..|.|..|.|..:.| :|::.  :...
  Rat   166 IFNDSTNIMHAKWLRLASGGSAHLDMFENISLMTLDTLQKCVFSFNSNCQEKP-SEYIAAILELS 229

  Fly   212 AIIERRYGGLL---DFLIFGFPKLSRRLRLKLNVQDVEDFYTSIV---RNTID-------YRLRT 263
            |::.:|...||   | |::......||.....::  |.||..:::   |.|:.       .:.:.
  Rat   230 ALVVKRNEQLLLHMD-LLYRLTPDGRRFYKACHL--VHDFTYAVIQERRRTLPKHGGDDVIKAKA 291

  Fly   264 NEKRHDFMDSLIEMYEKEQAGNTEDG--LSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQD 326
            ..|..||:|.|:       ....|||  ||..:|.|:|..|...|.:|:::.:.:.||.||...:
  Rat   292 KSKTLDFIDVLL-------LSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHPE 349

  Fly   327 IQDQLRAEINNVLSKHNNE--------FTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQTDFS 383
            .|::.|.|:..:|...::|        ...:.:.::.:|...:.|:||.:|.:..::|....|.|
  Rat   350 YQERCRQEVQELLRDRDSEEIECSCGVLLRDDLAQLPFLTMCIKESLRLHPPVTMVSRCCTQDIS 414

  Fly   384 PEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPRNCIGL 448
            ..|.: .|.||...:|.....|::|.::.:||.:.|.||..|.|.||....::||..|||||||.
  Rat   415 LPDGR-VIPKGIICIINIFATHHNPTVWQDPEVYDPFRFDPENIQARSPLAFIPFSAGPRNCIGQ 478

  Fly   449 RFGL--MQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKVEKLS 501
            .|.:  |:..|.|..|    :|.|..:.:.|.:  ...::|.||:|:.|:||.||
  Rat   479 TFAMNEMKVAVALTLL----RFRVLPDDKEPRR--KPELILRAEDGLWLRVEPLS 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	114/437 (26%)
Cyp4f40	XP_038935701.1	CYP4F	74..522	CDD:410772	114/438 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910