DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and cyp3c3

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001007401.2	Gene:	cyp3c3 / 492759	ZFINID:	ZDB-GENE-041114-102	Length:	503	Species:	Danio rerio

Alignment Length:	506	Identity:	147/506 - (29%)
Similarity:	265/506 - (52%)	Gaps:	58/506 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLLLTLIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMIFRDYYTKYKR 65
            :|:..||:.|:::||.......||::::.|||...|.|.:|....              |||
Zfish     7 LSVTWTLVFLVITLLYMYGVWPHGFFKKLGIPGPRPWPFFGTFLS--------------YTK--- 54

  Fly    66 SVYPFAGFYFFFTRSA-----------------VITDLELVKRVLIKD-FNHFENRGIFYNEIDD 112
                  ||:.|....|                 ::||||::|.:::|: ::.|.||.....::..
Zfish    55 ------GFFNFDMECAKKYGKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREVNVDLAG 113

  Fly   113 PLSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDL 177
            ||:..:.:::.::|:.:|..|:|.||||::|.:|||.:...:...|....:   ...|.::|.::
Zfish   114 PLADGISAVKDERWKRIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKR---DHEQPVKIKEV 175

  Fly   178 VARYTADVIGNCAFGLNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFGFPKLSRRL-RLKLN 241
            ||.|:.||:.:.:|.::.:|:.||:..|||..|..:....:..|:.||.. ||.::..| ::.::
Zfish   176 VAPYSLDVVTSSSFSVDIDSINNPDDPFVTNIKNFLKFSLFSPLILFLTL-FPSIANLLGKMGIS 239

  Fly   242 V--QDVEDFYTSIVRNTIDYRLRTNEKRHDFMDSLIE-MYEKEQAGNTED-----GLSFNEILAQ 298
            |  :.:.:|:.:.:|...|....:| .|.||:..:|: ....:||.:|..     ||:.:|||:|
Zfish   240 VFSRSIMNFFYTALRKIKDEHKDSN-GRVDFLRLMIQNQIPDDQAKDTTSEQPVKGLTDHEILSQ 303

  Fly   299 AFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVME 363
            :|||.:.|:||:|||:.|.|:.||.:.|..::|..||:..... :...:|:.:.:|.|||..:.|
Zfish   304 SFIFILGGYETTSTTLSFLLHNLATNPDCLEKLVEEIDKNFPL-DTPISYDALMKMDYLEMSINE 367

  Fly   364 TLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIA 428
            ::|..|....|.|:.:.  :.|.....|.|.|.|.||...::.||:::..|::|:||||:.|..:
Zfish   368 SMRLLPTAPRLERVCKK--TVELNGITIPKDTLVAIPTYVLNRDPQLWDSPQEFRPERFSPENKS 430

  Fly   429 ARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMK 479
            ......::|||.|||||||:||.||...:.:..|::.:......|||||::
Zfish   431 EFLQYAFMPFGLGPRNCIGMRFALMIVKLLVVKLLQNFSLETCKETQIPLE 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	136/471 (29%)
cyp3c3	NP_001007401.2	p450	38..496	CDD:278495	137/475 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm6472
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.720