Protein Alignment Cyp6a23 and cyp-25A3

DIOPT Version :10

• Sequence 1: NP_611000.2
• Gene: Cyp6a23 / 36661
• FlyBaseID: FBgn0033978
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_001040850.1
• Gene: cyp-25A3 / 4363046
• WormBaseID: WBGene00014697
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 526
• Identity: 151/526 - (28%)
• Similarity: 247/526 - (46%)
• Gaps: 63/526 - (11%)

  Fly     3 LLLTLIALLVSLLLFMARRRHGYWQRR---GIPHDVPHPIYGNMKDWPKKRHIAMIFR------- 57
            :|.:::..|||.::::...|...::.|   |:....||.:.||:|.        :|.|
 Worm     5 ILTSILVSLVSFIIYVILARKERFRLRGKIGLSGPEPHWLMGNLKQ--------IIERKAKLGYD 61

  Fly    58 ---DYYTKYKRSVYPFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENRG----IFYNEIDDPLS 115
               |:|.|..:......|.||....:..||:.|.:|.|.||:|::|.:|.    |..|::.:.|.
 Worm    62 DSYDWYNKLHKQFGETFGIYFGTQLNINITNEEDIKEVFIKNFSNFSDRTPPPIIEDNKLKESLL 126

  Fly   116 ATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVAR 180
            ...:.   ..|:|.|..:.|.|::||||.|...|....:...:|...|.::  ||..:|.|....
 Worm   127 QNTYE---SGWKHTRSAIAPIFSTGKMKAMHETIHSKVDLFLEILKEKASS--GQKWDIYDDFQG 186

  Fly   181 YTADVIGNCAFGLNCNSLQNPNAEFVTIGKRAI--IERRYGGLLDFLIFGFPKLSRRLRLKLNVQ 243
            .|.||||.|||.::.|..::.|..|....::.|  |:.|:..::. ..|.||:||:..::.....
 Worm   187 LTLDVIGKCAFAIDSNCQRDRNDVFYVNARKFITNIDIRHSKIIS-TSFLFPELSKLWKVLYRFT 250

  Fly   244 DVEDFYTSIVRNTID-YRLRTNEKRHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGF 307
            |:......:|....| |..|...:..|.:|.|..:..:|.  :....::..|::...|.|.:||:
 Worm   251 DLAKAEIPLVEGLADVYERRRGGEGSDSVDLLKLLLNRED--DKSKPMTKQEVIENCFAFLLAGY 313

  Fly   308 ETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLA 372
            ||:||.|.:..|.|:...::|.:|..||  :.:|.|...||:.|..||||:.|..||||.||.:.
 Worm   314 ETTSTAMTYCSYLLSKYPNVQQKLYEEI--MEAKENGGLTYDSIHNMKYLDYVYKETLRCYPPVI 376

  Fly   373 HLT-RMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTD-EAIAARPSCTW 435
            |.: |....|.:...  .|..||..||.....:|.:||.:..||:|.||||.: |..::  |..|
 Worm   377 HFSNRRCLKDITIRG--QFYPKGAIVVCLPHTVHRNPENWDSPEEFHPERFENWEEKSS--SLKW 437

  Fly   436 LPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGI------- 493
            :|||.|||.|:|:||..|:....:|.|:..::..         :|..::.|:...||:
 Worm   438 IPFGVGPRYCVGMRFAEMEFKTTIAKLLDTFELK---------QFEGEADLIPDCNGVIMRPKDP 493

  Fly   494 ---HLK 496
               |||
 Worm   494 VRLHLK 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	CYP6-like	68..494	CDD:410679	131/444 (30%)
cyp-25A3	NP_001040850.1	CYP3A-like	73..495	CDD:410678	131/444 (30%)