DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and Cyp4a30b

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	XP_006503285.1	Gene:	Cyp4a30b / 435802	MGIID:	3717145	Length:	510	Species:	Mus musculus

Alignment Length:	543	Identity:	132/543 - (24%)
Similarity:	230/543 - (42%)	Gaps:	97/543 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLTLIALLVSLLLFMARRR---HGYWQRRGIPHDVPHP----IYGN-MKDWPKKRHIAMIFRDYY 60
            ||.:::||..|||.:...:   |..|..:.:....|.|    ::|| :|| ...:.|.:....:.
Mouse    18 LLQVVSLLGLLLLLLKSAQYYLHRQWLIKSLQQFPPAPPPQWLFGNTLKD-QDLQQILLCVEKFP 81

  Fly    61 TKYKRSVYPFAGFYFFFTRSAVITDLELVKRVL-------IKDFNHFENRGIFYNEIDDP-LSAT 117
            :.|.|.::   |.:    ...||.|.:.:|.:|       ::.::.|.           | :...
Mouse    82 STYVRWLW---GNH----ARVVIYDPDYMKVILGRSDPKVVRSYSFFA-----------PWIGYG 128

  Fly   118 LFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIV-KVGEEMEKIFSAKTTTGEGQVLEIVDLVARY 181
            |..:.|:||...|..|||.|....:|....|:| .|...::|   .:....:...|||...::..
Mouse   129 LLLLNGKKWFQHRRMLTPAFHYDILKPYVGIMVDSVHVMLDK---WEQLVDQDCPLEIYQDISLM 190

  Fly   182 TADVIGNCAFGLNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIF-----GFPKLSRRLRLKLN 241
            |.:.:..|||... .|:|..:........:|:.:      |..||:     ||.:.:....|..|
Mouse   191 TMETMMKCAFSYQ-GSVQLEDCRNSKSYIKAVED------LTHLIYLRVRNGFHQNNTIYSLSSN 248

  Fly   242 VQDVEDFYTS----------IVR-------NTIDYRLRTNEKRHDFMDSLIEMYEKEQAGNTEDG 289
            .:   .||.:          ::|       |..:......:||.||:|.|:       ...||||
Mouse   249 GR---SFYHACQIAHKHTERVIRMRKAQLQNEAELEKFRKKKRLDFLDILL-------FAQTEDG 303

  Fly   290 --LSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIK 352
              ||..::.|:...|...|..|:::.:.:..|.||...:.|.:.|.|:.::|. :....|...:.
Mouse   304 KSLSDEDVRAEMDTFMFEGHNTTASGISWIFYALATHPEHQQRCREEVKSILG-NGTSVTLNHLD 367

  Fly   353 EMKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYF-----IAKGTTVVIPALGIHYDPEIYP 412
            :|.|....:.|.||.||.:...:|...:      |..|     :.||..|.:...|:|::|.:.|
Mouse   368 QMPYTTMCIKEALRLYPPIPGASRELSS------PVTFPDGCSLPKGFLVTLSFYGLHHNPRLRP 426

  Fly   413 EPEKFKPERFTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIP 477
            ..|.|.|.||...  |.|.:..:|||..|.|||||.:|.:.:..|.:|..:..::. :...|::|
Mouse   427 NAEVFDPSRFAPG--APRQTHAFLPFSAGTRNCIGKQFTMNELKVAVALTLLRFEL-LPDPTRVP 488

  Fly   478 MKFVVKSILLSAENGIHLKVEKL 500
            :  :|..|:|.::|||:|..:||
Mouse   489 I--LVSKIVLKSKNGIYLHTKKL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	120/501 (24%)
Cyp4a30b	XP_006503285.1	p450	59..504	CDD:365848	118/495 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910