DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a23 and Cyp6d4

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	174/522 - (33%)
Similarity:	289/522 - (55%)	Gaps:	36/522 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLLLTLIALLVSLLLFMARRRHGYWQRRGIPHD----VPHPIYGNMKD-WPKKRHIAMIFRDYY 60
            |..|:.|...|::|..|..:|.:.||:|||.|.:    :|   :|.:.. |.:::.:.:...|.|
  Fly     1 MFSLILLAVTLLTLAWFYLKRHYEYWERRGFPFEKHSGIP---FGCLDSVWRQEKSMGLAIYDVY 62

  Fly    61 TKYKRSVYPFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENRGIFYNEIDDPLSATLFSIEGQK 125
            .|.|..|   .|.|..|..:.:|.|.:|.:|||.:||..|.:||::.:|..|||||.:||:.||.
  Fly    63 VKSKERV---LGIYLLFRPAVLIRDADLARRVLAQDFASFHDRGVYVDEERDPLSANIFSLRGQS 124

  Fly   126 WRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEG-QVLEIVDLVARYTADVIGNC 189
            ||.:||.|:|.|||||:|:||.....:|::|..... |....|| :.::|..::..|..|:|.:.
  Fly   125 WRSMRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQ-KELPEEGFKEVDIKKVMQNYAIDIIAST 188

  Fly   190 AFGLNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFGFPKLSR---RLRLKLNVQDVEDFYTS 251
            .|||:.||.:||:.:|..:...|....|:..:...:||..|.:::   |:..|   ..|......
  Fly   189 IFGLDVNSFENPDNKFRKLVSLARANNRFNAMFGMMIFLVPSIAQFLFRIGFK---NPVGLAMLQ 250

  Fly   252 IVRNTIDYRLRTNEKRHDFMDSLIEMY------EKEQAG----NTEDG----LSFNEILAQAFIF 302
            ||:.|::||.:....|.|.:..||::.      |.::..    .|.||    :|...|.||||||
  Fly   251 IVKETVEYREKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTISLEAITAQAFIF 315

  Fly   303 FVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRK 367
            ::||.||:.:|..|.:||||...::..:|:.|::..|:|::.:.||:.:.:|::|:..|.||:||
  Fly   316 YIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNKMEFLDLCVQETIRK 380

  Fly   368 YPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPS 432
            ||.|..|.|....|::..|..:.|.|||.|||...|||:|.|.:|:||.:.||||::|:....|:
  Fly   381 YPGLPILNRECTQDYTVPDTNHVIPKGTPVVISLYGIHHDAEYFPDPETYDPERFSEESRNYNPT 445

  Fly   433 CTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKV 497
             .::|||||||.||..|.|.:.:.:.:..:::.:...|.:.::|  :|....|.|..::|:.:::
  Fly   446 -AFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEI--EFENSGIALIPKHGVRVRL 507

  Fly   498 EK 499
            .|
  Fly   508 SK 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	160/477 (34%)
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	156/451 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461188
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900