DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a23 and Cyp4d8

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	552	Identity:	133/552 - (24%)
Similarity:	234/552 - (42%)	Gaps:	110/552 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LIALLVSLLLFMA----------RRRHGYWQRRGIPHDVPHPIYGNMKDW----PKKRHIAMIFR 57
            ::..|:.:|||.|          |||    :...:|..:..|:.|.|:..    ||.  ...:.|
  Fly     1 MLLFLLVVLLFGAGWIIHLGQADRRR----KVANLPGPICPPLIGAMQLMLRLNPKT--FIKVGR 59

  Fly    58 DYYTKY---KRSVYPFAGFYFFFTRSAVIT-DLELVKRVLIKDFNHFENRGIFYNEIDDPLSATL 118
            :|..|:   :|        .:.|.|..::: |.||.:: |:....|.....: |..:...|...|
  Fly    60 EYVLKFGHLQR--------VWIFNRLLIMSGDAELNEQ-LLSSQEHLVKHPV-YKVLGQWLGNGL 114

  Fly   119 FSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTT--------TGEGQVLEIV 175
            ...:|:.|...|..:||||       .|.|:    |:..::|..::.        ...|...::.
  Fly   115 LLSDGKVWHQRRKIITPTF-------HFSIL----EQFVEVFDQQSNICVQRLAQKANGNTFDVY 168

  Fly   176 DLVARYTADVIGNCAFGLNCNSLQN---PNAEFVTIGKRAIIERRYGGLLDFLIFGFPKLSRRLR 237
            ..:.....|:|...|.|....:..|   |.||.|. ...|::..|:..:.         |...|.
  Fly   169 RSICAAALDIIAETAMGTKIYAQANESTPYAEAVN-ECTALLSWRFMSVY---------LQVELL 223

  Fly   238 LKLNVQDVEDFYTSIVRNTIDYRLRTNEKR----HDFMDSLIEMYEKEQAG------------NT 286
            ..|....::...|.::|...::.::..|||    .|....|::..:::...            :|
  Fly   224 FTLTHPHLKWRQTQLIRTMQEFTIKVIEKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMST 288

  Fly   287 EDG--LSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVL-SKHNNEFTY 348
            .||  |:.:||..:...|...|.:|:::.:.|.|:||:...::|.::..||..|| :..:...:.
  Fly   289 VDGRPLTNDEIREEVDTFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSI 353

  Fly   349 EGIKEMKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKY--------FIAKGTTVVIPALGIH 405
            ..:.|:||:|.|:.|:||.||.:..:.|..||||     ||        .|..|:.::|...|:|
  Fly   354 RDLGELKYMECVIKESLRMYPPVPIVGRKLQTDF-----KYTHSVHGDGVIPAGSEIIIGIFGVH 413

  Fly   406 YDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSV 470
            ..||.:|.|::|.|||..:.:..|  ....:||..|||||||.:|..::..:.||.::|.|:.
  Fly   414 RQPETFPNPDEFIPERHENGSRVA--PFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYEL-- 474

  Fly   471 STETQIPMKFVVK---SILLSAENGIHLKVEK 499
                 :||...|:   :|:|.:|.|..|.:.|
  Fly   475 -----LPMGQRVECIVNIVLRSETGFQLGMRK 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	122/507 (24%)
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	114/475 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940