Protein Alignment Cyp6a23 and Cyp46a1

DIOPT Version :10

• Sequence 1: NP_611000.2
• Gene: Cyp6a23 / 36661
• FlyBaseID: FBgn0033978
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_001386630.1
• Gene: Cyp46a1 / 362782
• RGDID: 1306605
• Length: 500
• Species: Rattus norvegicus
• Alignment Length: 491
• Identity: 118/491 - (24%)
• Similarity: 210/491 - (42%)
• Gaps: 60/491 - (12%)

  Fly     3 LLLTLIALLVSLLL---FMARRRHGYWQRRGIPHDVPHPIYGNMK-DWPKKRHIAMIFRDYYTKY 63
            |||...|:|::..|   |:.|.|..|....|.|.  |..:.|::. .|.|......:.:|.:..:
  Rat     5 LLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPR--PSFLLGHLPYFWKKDEACGRVLQDVFLDW 67

  Fly    64 KRSVYPFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENRGIFYNEIDDPLSATLFSIEGQ---- 124
            .:...|......|...|.::|..|.||:.|:.  ..:......|..|.......||   ||
  Rat    68 AKKYGPVVRVNVFHKTSVIVTSPESVKKFLMS--TKYNKDSKMYRAIQTVFGERLF---GQGLVS 127

  Fly   125 -----KWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQV-LEIVDLVARYTA 183
                 :|...|..:...|:...:.::.....:..|::.:|..||   .:||. :.:.|::...|.
  Rat   128 ECDYGRWYKQRRVMDLAFSRSSLVSLMGTFNEKAEQLMEILEAK---ADGQTPVSMQDMLTCATI 189

  Fly   184 DVIGNCAFGLNCNSL---QNPNAEFVTIGKRAIIERRYGGLLDFLIFGFPKLSRRLRLKLNVQDV 245
            |::...|||:..:.|   |.|.::.|.:....|...| ..|..|:    |...::||   .:::.
  Rat   190 DILAKAAFGMETSMLLGAQKPLSQAVKVMLEGISASR-NTLAKFM----PGKRKQLR---EIRES 246

  Fly   246 EDFYTSIVRNTIDYRLRTNEKRHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFI-FFVAGFET 309
            ......:.::.:..|....::..|....::....|.:.|..:|     |:|...|: ||:||.||
  Rat   247 IRLLRQVGKDWVQRRREALKRGEDVPADILTQILKAEEGAQDD-----EVLLDNFVTFFIAGHET 306

  Fly   310 SSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYP----- 369
            |:..:.|.:.||:...:|..:|:||::.|:.. .....||.:..::||.||:.|:||.||
  Rat   307 SANHLAFTVMELSRQPEIVARLQAEVDEVVGS-KRHLDYEDLGRLQYLSQVLKESLRLYPPAWGT 370

  Fly   370 --VLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPS 432
              :|...|.:.........|..|    :|.|:..:..:::     :|..|.|:||...  |.:|.
  Rat   371 FRLLEEETLIDGVRVPGNTPLLF----STYVMGRMDTYFE-----DPLTFNPDRFGPG--APKPR 424

  Fly   433 CTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKF 468
            .|:.||..|.|:|||.:|..|:..|.:|.|::..:|
  Rat   425 FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEF 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	CYP6-like	68..494	CDD:410679	101/422 (24%)
Cyp46a1	NP_001386630.1	CYP46A1-like	61..484	CDD:410706	102/433 (24%)