DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a23 and Cyp4e2

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	133/563 - (23%)
Similarity:	243/563 - (43%)	Gaps:	111/563 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLLTLIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPK--KRHIAMIFRDYYTKYKR 65
            :.|.|..|||:.|.....||.....:...|..:  |:.||.....|  ...:..:| .::.:|.:
  Fly     7 IFLALPLLLVAYLELSTFRRRRVLNKFNGPRGL--PLMGNAHQMGKNPSEILDTVF-SWWHQYGK 68

  Fly    66 SVYPF-AGFY------------FFFTRSAVITDLELVKRVLIKDFNHFENRGIFYNEIDDP-LSA 116
            ..:.| .|.|            |..:...:||..::.                   ::..| |..
  Fly    69 DNFVFWIGTYSNVLVTSSKYLEFILSSQTLITKSDIY-------------------QLTHPWLGL 114

  Fly   117 TLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEK-IFSAKTTTGEGQVLEIVDLVAR 180
            .|.:..|.||...|..:||.|....:::...:   :.|...| |...||......:.:..:....
  Fly   115 GLLTSTGSKWHKHRKMITPAFHFNILQDFHEV---MNENSTKFIKHLKTVAAGDNIFDFQEQAHY 176

  Fly   181 YTADVIGNCAFGLNCNSLQNPNAEFV--------TIGKRAIIERRYGGLLDFLIFGFPKLSRRLR 237
            .|.|||.:.|.|::.|:::|.::..|        .|..||....:...||..|...:|..||.|:
  Fly   177 LTLDVICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLK 241

  Fly   238 LKLNVQDVEDFYTSIVRNTIDYR----LRTN------EKRHDFMDSLIEMYEKEQAGNTEDG--L 290
                  .::||...|:...|:..    :.||      .|:..|:|:|:        .:|.||  |
  Fly   242 ------TLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLL--------SSTIDGRPL 292

  Fly   291 SFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVL--SKHNNEFTYEGIKE 353
            :..|:..:...|...|.:|:::.:.||:|.|:..||.|.:|..|...|:  |:...:.|::.|.:
  Fly   293 NSKELYEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQ 357

  Fly   354 MKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFK 418
            ||||:..:.|..|.||.:..:.|.|:.|:..:..  .:.||||:.:..:.:.|:.:::.:|.||:
  Fly   358 MKYLDLFIKEAQRVYPSVPFIGRFTEKDYVIDGD--LVPKGTTLNLGLVMLGYNEKVFKDPHKFR 420

  Fly   419 PERFTDEAIAARPS-CTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKF------------SV 470
            ||||..|    :|. ..::||..|||||||.:|.|::....::.:||.::.            .:
  Fly   421 PERFELE----KPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYI 481

  Fly   471 STETQIP-----------MKF--VVKSIL-LSAENGIHLKVEK 499
            ||...:|           .|:  ::.::| |.:|||:::::::
  Fly   482 STTIGLPDAERKKRDPYRHKYDPILSAVLTLKSENGLYIRLKE 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	124/524 (24%)
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	116/478 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.820