DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a23 and Cyp9b2

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	495	Identity:	159/495 - (32%)
Similarity:	248/495 - (50%)	Gaps:	38/495 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLLLTLIALLV--SLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWP-KKRHIAMIFRDYYTK 62
            |:|:...:||:|  .|:...:......::.|.:..:.|:|..|||.... :|........::|.:
  Fly     1 MALIEICLALVVIGYLIYKWSTATFKTFEERKLYFEKPYPFVGNMAAAALQKSSFQRQLTEFYER 65

  Fly    63 YKRSVYPFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENRGIFYNEIDDPLSATLFSIEGQKWR 127
            .::  :...||:...|....:.|.||:|:|.:|||:||.|...|....|...:..|..:..|:|:
  Fly    66 TRQ--HKLVGFFNMRTPMITLNDPELIKKVCVKDFDHFPNHQPFITSNDRLFNDMLSVMRDQRWK 128

  Fly   128 HLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIF---------SAKTTTG-EGQVLEIVDLVARYT 182
            |:|:.|||.||:.||:|||.:       |.:.|         |:||..| :|..:::..:..:.:
  Fly   129 HMRNTLTPVFTAAKMRNMFTL-------MNESFAECLQHLDSSSKTLPGRKGFEVDMKVMCNKLS 186

  Fly   183 ADVIGNCAFGLNCNSLQNPNAEFVTIGKRAIIERR---YGGLLDFLIFGFPKLSRRLRLKLNVQD 244
            .|:|...||||..||..||..||..||:..:..|.   :..:|..|:   |||...|:|.:....
  Fly   187 NDIIATTAFGLKVNSYDNPKNEFYEIGQSLVFSRGLQFFKFMLSTLV---PKLFSLLKLTIFDSA 248

  Fly   245 VEDFYTSIVRNTIDYRLRTNEKRHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFET 309
            ..|::..:|...:.||.:.|..|.|.:..|:     |....:||..:.:||:||.||||.|.||.
  Fly   249 KVDYFARLVVEAMQYREKHNITRPDMIQLLM-----EAKNESEDKWTDDEIVAQCFIFFFAAFEN 308

  Fly   310 SSTTMGFALYELALDQDIQDQLRAEINNVLSKHNN-EFTYEGIKEMKYLEQVVMETLRKYPVLAH 373
            :|..:....|||..:.|:|::|..||.......|. ..||:.:::|.|::.|:.|:|||:.:.|.
  Fly   309 NSNLICTTTYELLYNPDVQERLYEEIVETKKALNGAPLTYDAVQKMTYMDMVISESLRKWTLAAA 373

  Fly   374 LTRMTQTDFSPED---PKYFIAK-GTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCT 434
            ..|:...|::..|   .|.|..| |..:.||..|:|.|...:|||.||.|:||::|........|
  Fly   374 TDRLCSKDYTLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPRKFDPDRFSEERKGDMVPYT 438

  Fly   435 WLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTET 474
            :||||.|||||||.|:.|||....|..|:..||...|..|
  Fly   439 YLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKIEASPRT 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	152/458 (33%)
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	151/457 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461260
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800