DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and Cyp9b1

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	501	Identity:	161/501 - (32%)
Similarity:	247/501 - (49%)	Gaps:	59/501 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LTLIALLVSLLLFMARRRHGYW--------QRRGIPHDVPHPIYGNM-KDWPKKRHIAMIFRDYY 60
            :.|:...:.||||.       |        :.|.:..:.|:|..||| ....:|........::|
  Fly     6 ICLVLATIGLLLFK-------WSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQISEFY 63

  Fly    61 TKYKRSVYPFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENRGIFY--NE--IDDPLSATLFSI 121
            .:.:.  :...|.:...|....|.|.:|:|::.:|||:||.|.....  ||  ::|.|:.    :
  Fly    64 NRTRH--HKLVGLFNLRTPMIQINDPQLIKKICVKDFDHFPNHQTLNIPNERLVNDMLNV----M 122

  Fly   122 EGQKWRHLRHKLTPTFTSGKMKNMFPII-VKVGEEMEKIFSAK-TTTGEGQV-LEIVDLVARYTA 183
            ..|.||::|..|||.|||.||:|||.:: ....:.:|.:.|:: ...||... |::..|..:.:.
  Fly   123 RDQHWRNMRSVLTPVFTSAKMRNMFTLMNESFAQCLEHLKSSQPIAAGENAFELDMKVLCNKLSN 187

  Fly   184 DVIGNCAFGLNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFGF----PKLSRRLRLKLNVQD 244
            |||...||||..||..:|..||.||||.....|.    |.||.|..    ||:....:|.:....
  Fly   188 DVIATTAFGLKVNSFDDPENEFHTIGKTLAFSRG----LPFLKFMMCLLAPKVFNFFKLTIFDST 248

  Fly   245 VEDFYTSIVRNTIDYRLRTNEKRHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFET 309
            ..:::..:|.:.:.||.:.|..|.|.:..|:|. :||...|..|    :||:||.||||.|.||.
  Fly   249 NVEYFVRLVVDAMQYREKHNITRPDMIQLLMEA-KKESKDNWTD----DEIVAQCFIFFFAAFEN 308

  Fly   310 SSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNE------FTYEGIKEMKYLEQVVMETLRKY 368
            :|..:....|||..:.|||::|..|:     |...|      .||:..:||.|::.|:.|:|||:
  Fly   309 NSNLICTTAYELLRNLDIQERLYEEV-----KETQEALKGAPLTYDAAQEMTYMDMVISESLRKW 368

  Fly   369 PVLAHLTRMTQTDFS---PEDPKYFIAK-GTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAA 429
            .:.|...|:...|::   .|..|.|..| |..:.||..|:|:|...:|:|::|.||||::.....
  Fly   369 TLSAAADRLCAKDYTLTDDEGTKLFEFKAGDNINIPICGLHWDERFFPQPQRFDPERFSERRKKD 433

  Fly   430 RPSCTWLPFGEGPRNCIGLRFGLMQACVGLAY-LIRGYKFSVSTET 474
            ....|:||||.|||:|||.|:.:||| .|:.| |:..||...|..|
  Fly   434 LIPYTYLPFGVGPRSCIGNRYAVMQA-KGMLYNLMLNYKIEASPRT 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	154/462 (33%)
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	153/461 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461272
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800