DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and Cyp310a1

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_609891.1	Gene:	Cyp310a1 / 35115	FlyBaseID:	FBgn0032693	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	122/528 - (23%)
Similarity:	231/528 - (43%)	Gaps:	74/528 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLLLTLIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKK--RHIAMIFRDYYTKY 63
            |.|||.:  ||.|.:....|..:.:|:|||.|.:.....:..::...::  ||:..|...|.:..
  Fly     1 MWLLLPI--LLYSAVFLSVRHIYSHWRRRGFPSEKAGITWSFLQKAYRREFRHVEAICEAYQSGK 63

  Fly    64 KRSVYPFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENRGIFYNEIDDPLSATLFSIEGQKWRH 128
            .|    ..|.|.||....::.::||.:.:|.:...||......|             |.|.:..:
  Fly    64 DR----LLGIYCFFRPVLLVRNVELAQTILQQSNGHFSELKWDY-------------ISGYRRFN 111

  Fly   129 LRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEG--QVLEIVDLVARYTADVIGNCAF 191
            |..||.|.|.:.::..||..:.|||:.:  |.......|:|  |.::|...:..|:.::|.|..:
  Fly   112 LLEKLAPMFGTKRLSEMFGQVQKVGDHL--IHHLLDRQGQGCPQEVDIQQKLRVYSVNIIANLIY 174

  Fly   192 GLNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFGFP-KLSRRLRLKLNVQDVEDFYTSIVRN 255
            ||:.|:.::.: ..:|    :.:......:..|.:...| |.|...||:           .:::.
  Fly   175 GLDINNFEHED-HILT----SYLSHSQASIQSFTLGRLPQKSSYTYRLR-----------DLIKQ 223

  Fly   256 TIDYRLRTNEKRHDFMDSLI----------EMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFETS 310
            :::.|......|.|.:..|:          :.::.|...:.:..||...:...|........:..
  Fly   224 SVELREDHGLIRKDILQLLVRFRNGNEVSGDKWQLEPINDADKLLSIKRLAKVAEDLLKVSLDAV 288

  Fly   311 STTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLT 375
            ::|:.|.|.|:..:..|.::|||||.. ||..|.:..:|.:..::|::..:.|||||||.|..:.
  Fly   289 ASTVTFTLLEILQEPLIVEKLRAEIKE-LSNENGQLKFEELNGLRYMDMCLKETLRKYPPLPIIE 352

  Fly   376 RMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAA------RPSCT 434
            |:.:..:|..:.|:.|.:|.|:::|.|.:|.|.:.:.||.|:||.||...|...      ..|..
  Fly   353 RVCRKSYSLPNSKFTIDEGKTLMVPLLAMHRDEKYFSEPMKYKPLRFLQTANDVGQCEDKTKSNV 417

  Fly   435 WLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLS--------AEN 491
            ::.||.|...|:|..|..:...|.|..|::.:...:....       ||::.:|        .::
  Fly   418 FIGFGIGGSQCVGQNFAKLVIKVALIKLLQNFHLELDANQ-------VKTLKVSHRPAPFIHTKD 475

  Fly   492 GIHLKVEK 499
            |:.:|:::
  Fly   476 GLKVKLKR 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	108/487 (22%)
Cyp310a1	NP_609891.1	p450	69..454	CDD:299894	98/416 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461200
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	180	1.000	Inparanoid score	I2666
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	7.900