DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and Cyp28a5

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_609694.1	Gene:	Cyp28a5 / 34817	FlyBaseID:	FBgn0028940	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	527	Identity:	145/527 - (27%)
Similarity:	257/527 - (48%)	Gaps:	54/527 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLLTLIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKD-WPKKRHIAMIFRDYYTKYKRS 66
            :.|||::|:|.||..:....:.||::||:|...|..:.||..: :..|||......|.|.:||..
  Fly     4 ITLTLVSLVVGLLYAVLVWNYDYWRKRGVPGPKPKLLCGNYPNMFTMKRHAIYDLDDIYRQYKNK 68

  Fly    67 VYPFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENRGIFYNEIDDP----LSATLFSIEGQKWR 127
             |...|.:...:...::.:..|.:||.:.:|.:|.:..|..| ||:.    .:...||:.|:||:
  Fly    69 -YDAVGIFGSRSPQLLVINPALARRVFVSNFKNFHDNEIAKN-IDEKTDFIFANNPFSLTGEKWK 131

  Fly   128 HLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNCAFG 192
            ..|..:||..|.|::|.::|:..||.:::.:....:...|....::...:...:|.:::.:|..|
  Fly   132 TRRADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLRLGSKDGIDAKHMSLCFTTEMVTDCVLG 196

  Fly   193 LNCNSLQNPNAEFVTIGKRAIIERRYGGLLD----FLIF-----GFPKLSRRLRLKLNVQDVEDF 248
            |...|..:         |...|..:...|.:    |::|     .||.||..::|:....|||.|
  Fly   197 LGAESFSD---------KPTPIMSKINDLFNQPWTFVLFFILTSSFPSLSHLIKLRFVPVDVERF 252

  Fly   249 YTSIVRNTIDYR---LRTNE--KRHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFE 308
            :..::.:.::.|   |...:  :|.||:|.::::.||....|       .::||.:..|.:.|||
  Fly   253 FVDLMGSAVETRRAQLAAGKQFERSDFLDYILQLGEKRNLDN-------RQLLAYSMTFLLDGFE 310

  Fly   309 TSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAH 373
            |::|.:...|..|..:::.|:.||.||.:.|  .:....:|.:.::.||:..|.||:|.:|. ..
  Fly   311 TTATVLAHILLNLGRNKEAQNLLREEIRSHL--QDGTIAFEKLSDLPYLDACVQETIRLFPP-GF 372

  Fly   374 LTRMTQTDF----SPEDPKYFIAKGTTVVIPALGIHY----DPEIYPEPEKFKPERF--TDEAIA 428
            ::....|:.    :.|.|.:.:.||||||:|    ||    |.|.:|.|:.|:||||  .|.|..
  Fly   373 MSNKLCTESIEIPNKEGPNFVVEKGTTVVVP----HYCFMLDEEFFPNPQSFQPERFLEPDAAKT 433

  Fly   429 ARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGI 493
            .|....::.||:|||.|||:||..:|....:..||..:...::.:|:....:....|:.....||
  Fly   434 FRERGVFMGFGDGPRVCIGMRFATVQIKAAIVELISKFNVKINDKTRKDNDYEPGQIITGLRGGI 498

  Fly   494 HLKVEKL 500
            .|.:|||
  Fly   499 WLDLEKL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	129/487 (26%)
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	130/491 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460972
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900