DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and Cyp28d2

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	128/515 - (24%)
Similarity:	246/515 - (47%)	Gaps:	40/515 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLLTLIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKD-WPKKRHIAMIFRDYYTKYKRS 66
            |:|||:.|:...|.:    ...||::|||......|..|:... :.:||:||....|.|.||| .
  Fly    10 LVLTLLVLVYVFLTW----NFNYWRKRGIKTAPTWPFVGSFPSIFTRKRNIAYDIDDIYEKYK-D 69

  Fly    67 VYPFAGFYFFFTRSAVITDLELVKRVLIKDFNHFEN---RGIFYNEIDDPLSATLFSIEGQKWRH 128
            .....|.:.......::...|.:.::...||..|.|   |.....:.|..|....|.:.|.:|:.
  Fly    70 TDNMVGVFTTRVPQLLVMCPEYIHKIYATDFRSFHNNEWRNFVNKKTDMILGNNPFVLTGDEWKE 134

  Fly   129 LRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNCAFGL 193
            .|.::.|..:..::|.::|:...|.::..:....:......:.|:.:||...||.:|:.:|..|:
  Fly   135 RRSEIMPALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMATSEGLDAMDLSLCYTTEVVSDCGLGV 199

  Fly   194 NCNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFG-FPKLSRRLRLKLNV----QDVEDFYTSIV 253
            :..|..:.....:     .:|:|.:....:|:.:. ...|.:::|...:|    ::.|.|:..|:
  Fly   200 SAQSFTDTPTPLL-----KMIKRVFNTSFEFIFYSVVTNLWQKVRKFYSVPFFNKETEVFFLDII 259

  Fly   254 RNTIDYRL-RTNEKRHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFETSSTTMGFA 317
            |..|..|| :..::|.||::.::::.||:       ||..:.||.....|.:.||||::..:...
  Fly   260 RRCITLRLEKPEQQRDDFLNYMLQLQEKK-------GLHTDNILINTMTFILDGFETTALVLAHI 317

  Fly   318 LYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKY-PVLAHLTRMTQT- 380
            :..|..:.:.||::|.||.:.      :.|::.:.|:.:|:..:.||||.: |.:|....:|:.
  Fly   318 MLMLGRNPEEQDKVRKEIGSA------DLTFDQMSELPHLDACIYETLRLFSPQVAARKLVTEPF 376

  Fly   381 DFSPEDPK-YFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDE----AIAARPSCTWLPFGE 440
            :|:.::.: ..:..|..|.||...:|:||:.|.:|..||||||.:.    ..:.|....:|.||:
  Fly   377 EFANKNGRTVHLKPGDVVTIPVKALHHDPQYYEDPLTFKPERFLESNGGGMKSYRDRGVYLAFGD 441

  Fly   441 GPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKVEKL 500
            |||:|.|:||.|.|....|..::|.::..|:.:|:...:......:.:.:.||:|..:.|
  Fly   442 GPRHCPGMRFALTQLKAALVEILRNFEIKVNPKTRSDNQIDDTFFMATLKGGIYLDFKDL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	115/475 (24%)
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	112/455 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460960
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	7.900