DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and Cyp6t1

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	178/522 - (34%)
Similarity:	265/522 - (50%)	Gaps:	45/522 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLLTLIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMI---FRDYYTKYK 64
            ||:..|..|..:|.|.      :|:|.|:|.....|..||:  |...|.....   ||:.|...:
  Fly    29 LLVVTIVWLWQILHFW------HWRRLGVPFVPAAPFVGNV--WNLLRGACCFGDQFRELYESKE 85

  Fly    65 RSVYPFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENRGIFYNEIDDPL-----SATLFSIEGQ 124
            .:...|.|.......:.::.|..|:||::::||..|.:|    .|..||.     |..||..:.:
  Fly    86 AAGRAFVGIDVLHNHALLLRDPALIKRIMVEDFAQFSSR----FETTDPTCDTMGSQNLFFSKYE 146

  Fly   125 KWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNC 189
            .||.......|.|.:||::||:.::..:|:::|:....|.:..:...||:..|.|.:|.|:|.:.
  Fly   147 TWRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEHMEQKLSGRDSMELEVKQLCALFTTDIIASL 211

  Fly   190 AFGLNCNSLQNPNAEFVTIGKRAIIE---RRYGGLLD-FLIFGFPKLSRRLRLKLNVQDVEDFYT 250
            |||:..:|||||.|||    :|..||   .|...||. |.:|.||:||.|:...|..::.|.|
  Fly   212 AFGIEAHSLQNPEAEF----RRMCIEVNDPRPKRLLHLFTMFFFPRLSHRVGTHLYSEEYERF-- 270

  Fly   251 SIVRNTIDY----RLRTNEKRHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFETSS 311
              :|.::||    |..:.|.|||.:|..:::...|.|.:......|  ..|||....:|||:|||
  Fly   271 --MRKSMDYVLSQRAESGENRHDLIDIFLQLKRTEPAESIIHRPDF--FAAQAAFLLLAGFDTSS 331

  Fly   312 TTMGFALYELALDQDIQDQLRAEINNVL-SKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLT 375
            :|:.|||||||.:..|||:||.|:...| |..:.:.:.:.:..:.||.|||.|.||.||..|.|.
  Fly   332 STITFALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEVLRLYPPTAFLD 396

  Fly   376 R----MTQTDFSPED--PKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCT 434
            |    .|..|.||.:  ..:.:..||.|.|..||||.|.:.:|.||.|.||||:.|........|
  Fly   397 RCCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDPERFSAEQRQQHHPMT 461

  Fly   435 WLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKVEK 499
            :||||.|||.|||...|.::..|||.:::..::..|...|...|:|..|:.:|:|.||.:|:..|
  Fly   462 YLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERTLPEMRFDPKAFVLTAHNGTYLRFVK 526

  Fly   500 LS 501
            .|
  Fly   527 NS 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	165/481 (34%)
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	153/437 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461068
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.900