DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a23 and Cyp6v1

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	177/529 - (33%)
Similarity:	283/529 - (53%)	Gaps:	44/529 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SLLLTLIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPK-KRHIAMIFRDYYTKYKR 65
            ::||.::.:|..:.:: :||.:.|||||.:....|..:.||:....: :...|:..|.:|...:.
  Fly     6 NILLAIVTILTGVFIW-SRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFALQLRRFYFDERF 69

  Fly    66 SVYPFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENRGIFYNEIDDPLSA-TLFSIEGQKWRHL 129
            ...|..|.|.|...:.:|.||:||:.||::||..|.||....:...|.:.| :||..:..:||.:
  Fly    70 RNEPVVGIYLFHQPALLIRDLQLVRTVLVEDFVSFSNRFAKCDGRSDKMGALSLFLAKQPEWREI 134

  Fly   130 RHKLTPTFTSGKMKNMFPIIVKVGEEME---KIFSAKTTTGE---GQVLEIVDLVARYTADVIGN 188
            |.:|.|.|...|:|.||.::.::|.::|   |..:.....|:   |.::.|.|:...|..|:|.:
  Fly   135 RTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSIKDVCDLYNTDMIAS 199

  Fly   189 CAFGLNCNSLQNPNAEFVTIGK------RAIIERRYGGLLD-FLIFGFPKLSRRLRLKLNVQDVE 246
            .||||...||:|..:|   ||.      |..:.|    ::| |:||..|||...||.||..:...
  Fly   200 IAFGLRSYSLRNTQSE---IGSHCQDLFRPNVRR----IIDLFVIFYLPKLVPLLRPKLFTEPHA 257

  Fly   247 DFYTSIVRNTIDYRLRTNEKRHDFMDSLIEMYEKEQAGNTEDGLSFNE----ILAQAFIFFVAGF 307
            :|...:::..|:.|.|..:.|:|.::.|:.:  |::|...:|...|..    :.|||..|.|||.
  Fly   258 EFLRRVIQLVIEERERGGDLRNDLIEMLLTL--KKEADLQQDKSHFTHHRDFLAAQAASFEVAGI 320

  Fly   308 ETSSTTMGFALYELALDQDIQDQLRAEINNVL-SKHNNEFTYEGIKEMKYLEQVVMETLRKYPVL 371
            ||.|.:|.|||||||....:|.:||.||.... |..|...|||.:..|::|:.||.|||||||::
  Fly   321 ETCSASMSFALYELAKQPLMQSRLRREIREAFASNPNGRLTYEAVARMEFLDMVVEETLRKYPIV 385

  Fly   372 AHLTRMTQTDFSPEDPKYFIA----------KGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEA 426
            ..|.|    :.:|.:.|.|.:          :|..|.|..|.||:||:.:|:|::|.||||:...
  Fly   386 PLLER----ECTPINKKRFYSLRPHAECYTRRGMPVFISNLAIHHDPKYWPDPDRFDPERFSAAN 446

  Fly   427 IAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAEN 491
            .|.:...:::|||.|||||||::.||:|..:||.|.:..::..:...|...::|..|..||::|.
  Fly   447 KALQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRTVERIQFDAKFALLASEQ 511

  Fly   492 GIHLKVEKL 500
            .|:|||:.|
  Fly   512 RIYLKVDCL 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	163/488 (33%)
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	160/470 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461116
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900