DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and cyp3c1

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_997838.1	Gene:	cyp3c1 / 324340	ZFINID:	ZDB-GENE-030131-3060	Length:	505	Species:	Danio rerio

Alignment Length:	490	Identity:	156/490 - (31%)
Similarity:	255/490 - (52%)	Gaps:	26/490 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLLLTLIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMIFRDYYTKYKR 65
            :|:..||:.|:::|||......||::::.|||...|.|..|....:.|  .|.....:...||.:
Zfish     7 LSVTWTLVVLVITLLLIYGVWPHGFFKKLGIPGPRPLPFVGTALSYSK--GICNFDIECSKKYGK 69

  Fly    66 SVYPFAGFYFFFTRSAVITDLELVKRVLIKD-FNHFENRGIFYNEIDDPLSATLFSIEGQKWRHL 129
             |:   |.|.......::||||::|.:|:|| ::.|.||.....::..|.:..:..::.::||.:
Zfish    70 -VW---GIYDGRLPLLLVTDLEMIKTILVKDCYSTFTNRRNMNPDLVGPFADGITLVKDERWRRI 130

  Fly   130 RHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNCAFGLN 194
            |..|:|.||||::|.:|||.:...:...|....|   .....|:|.|:||.|:.||:.:.:|.::
Zfish   131 RSSLSPYFTSGRLKEIFPIAMTHADRFIKNMEKK---DPNLPLKIKDVVAPYSLDVVASSSFSVD 192

  Fly   195 CNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFGFPKLSRRLRLKLNV----QDVEDFYTSIVRN 255
            .:|:.||:..|||..|..........|  ||:..|...:..|..|:.:    :...|||...:|.
Zfish   193 FDSINNPDDPFVTSIKSFFNINPLSPL--FLLLAFCPSAANLLAKMGISVFSRSTTDFYYKALRK 255

  Fly   256 TIDYRLRTNEKRHDFMDSLIE-MYEKEQAGNTED-----GLSFNEILAQAFIFFVAGFETSSTTM 314
            ..|....:| .|.||:..:|: ....:|..:|..     ||:.:|||:|:|||.:.|:||:|||:
Zfish   256 IKDEHNESN-GRVDFLKLMIQNQIPDDQVKDTASEQPVKGLTDHEILSQSFIFILGGYETTSTTL 319

  Fly   315 GFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQ 379
            .:.||.||.:.|..::|..||:..... :...||:.:..|.|||..:.|::|.:|....|.|:.:
Zfish   320 SYLLYNLATNPDCLEKLVEEIDKNFPL-DIPITYDALMRMDYLEMAIHESMRVFPAGPRLERVCK 383

  Fly   380 TDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPRN 444
            .  :.|.....|.|.|.|.||...:..||:::..|.:||||||:.|:......|.::|||.||||
Zfish   384 K--TVEINGITIPKNTLVGIPLYVLSRDPDLWESPNEFKPERFSPESKTEINQCAFMPFGLGPRN 446

  Fly   445 CIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMK 479
            |||:||.||...:.:..|::.|......|||||::
Zfish   447 CIGMRFALMMMKLLVVKLLQKYTVETCKETQIPVQ 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	144/455 (32%)
cyp3c1	NP_997838.1	p450	38..496	CDD:278495	145/459 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm6472
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.750