Protein Alignment Cyp6a23 and CYP4V2

DIOPT Version :9

• Sequence 1: NP_611000.2
• Gene: Cyp6a23 / 36661
• FlyBaseID: FBgn0033978
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_997235.3
• Gene: CYP4V2 / 285440
• HGNCID: 23198
• Length: 525
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 134/543 - (24%)
• Similarity: 229/543 - (42%)
• Gaps: 89/543 - (16%)

  Fly     2 SLLLTLIALLVSLLLFMARRRHGYWQRRGIPHDV-PHPIYGN---MKDWPKKRHIAMIFRDYYTK 62
            :|.|...:|::|||..:|.....:.|.|.||... .:|:.|:   ||  |..|.......:|..:
Human    21 ALSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHALLMK--PDGREFFQQIIEYTEE 83

  Fly    63 YKR--------SVYPFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENRGIFYNEIDDPLSATLF 119
            |:.        ...|....|.......::|..:.:            ::...|..::..|...|.
Human    84 YRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQI------------DKSSMYKFLEPWLGLGLL 136

  Fly   120 SIEGQKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQ-VLEIVDLVARYTA 183
            :..|.|||..|..|||||....:::...|:    .|...|...|......| .......:.....
Human   137 TSTGNKWRSRRKMLTPTFHFTILEDFLDIM----NEQANILVKKLEKHINQEAFNCFFYITLCAL 197

  Fly   184 DVIGNCAFGLNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFGFPKLSRRLRL---------- 238
            |:|...|.|.|..:..|.::|:|    ||:..      :..:||      ||:::
Human   198 DIICETAMGKNIGAQSNDDSEYV----RAVYR------MSEMIF------RRIKMPWLWLDLWYL 246

  Fly   239 --------KLNVQDVEDFYTSIVRNTIDYRLRTNE--------------KRHDFMDSLIEMYEKE 281
                    |.::|.:..|..|::....: .:..||              ||..|:|.|:.:.:.|
Human   247 MFKEGWEHKKSLQILHTFTNSVIAERAN-EMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDE 310

  Fly   282 QAGNTEDGLSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEF 346
              ||.   ||..:|..:...|...|.:|::..:.::||.|..:.::|.::..|:::|..|.:...
Human   311 --GNR---LSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPA 370

  Fly   347 TYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIY 411
            |.|.:|:::|||.|:.||||.:|.:....|....|.  |...|.:.|||..||....:|.||..:
Human   371 TVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDC--EVAGYRVLKGTEAVIIPYALHRDPRYF 433

  Fly   412 PEPEKFKPERFTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQI 476
            |.||:|:||||..|....|....::||..|||||||.:|.:|:....|:.::|  .|.:.:..:.
Human   434 PNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILR--HFWIESNQKR 496

  Fly   477 PMKFVVKSILLSAENGIHLKVEK 499
            ....:...::|...|||.:|:::
Human   497 EELGLEGQLILRPSNGIWIKLKR 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	122/502 (24%)
CYP4V2	NP_997235.3	p450	55..517	CDD:278495	122/505 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820