DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a23 and CYP4A22

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001010969.2	Gene:	CYP4A22 / 284541	HGNCID:	20575	Length:	519	Species:	Homo sapiens

Alignment Length:	538	Identity:	128/538 - (23%)
Similarity:	233/538 - (43%)	Gaps:	90/538 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SLLLTLIALLVSLLLFMARRRHGYWQRRGI---PHDVPHPIYGNMKDWPKKRHIAMIFRDYYTKY 63
            |||:.|:.|:.:..|::    |..|..:.:   |....|.::|:::::...:.:..|      :.
Human    23 SLLILLLLLIKAAQLYL----HRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRI------QE 77

  Fly    64 KRSVYPFAGFYFFFTRSAVIT--DLELVKRVLIKDFNHFENRGIFYNEIDDPLSATLFSIEGQKW 126
            :...:|.|..|:.:.....:.  |.:.:|.:|.:  :..::.| .|..:...:...|..:.||.|
Human    78 RVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGR--SDPKSHG-SYKFLAPRIGYGLLLLNGQTW 139

  Fly   127 RHLRHKLTPTFTS-------GKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTAD 184
            ...|..|||.|.:       |.|.:...:::...||:         .|:...||:...|:..|.|
Human   140 FQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEEL---------LGQDSPLEVFQHVSLMTLD 195

  Fly   185 VIGNCAFGLNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFGFPKLSRRLRLKLNVQDVEDFY 249
            .|...||....:...:.|::...   :||.:      |:.|:|..      :|...:..|.....
Human   196 TIMKSAFSHQGSIQVDRNSQSYI---QAISD------LNSLVFCC------MRNAFHENDTIYSL 245

  Fly   250 TSIVRNT--------------IDYRL----------RTNEKRH-DFMDSLIEMYEKEQAGNTEDG 289
            ||..|.|              |..|.          :...||| ||:|.|:       ....|:|
Human   246 TSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILL-------LAKMENG 303

  Fly   290 --LSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIK 352
              ||..::.|:...|...|.:|:::.:.:.||.||.....|::.|.||:.:|. .....|:..:.
Human   304 SILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLG-DGASITWNHLD 367

  Fly   353 EMKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKF 417
            :|.|....:.|.||.||.:..:.|...|..:..|.: .:.||..|::...|:|::|:::|..|.|
Human   368 QMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNLEVF 431

  Fly   418 KPERFTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVV 482
            .|.||...  :|:.|..:|||..|.|||||.:|.:.|..|..|..:..::. :...|:||:.  :
Human   432 DPSRFAPG--SAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFEL-LPDPTRIPIP--M 491

  Fly   483 KSILLSAENGIHLKVEKL 500
            ..::|.::|||||::.:|
Human   492 ARLVLKSKNGIHLRLRRL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	116/494 (23%)
CYP4A22	NP_001010969.2	p450	52..505	CDD:278495	118/499 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900