Protein Alignment Cyp6a23 and Cyp4a12a

DIOPT Version :10

• Sequence 1: NP_611000.2
• Gene: Cyp6a23 / 36661
• FlyBaseID: FBgn0033978
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_803125.2
• Gene: Cyp4a12a / 277753
• MGIID: 88612
• Length: 508
• Species: Mus musculus
• Alignment Length: 557
• Identity: 132/557 - (23%)
• Similarity: 234/557 - (42%)
• Gaps: 134/557 - (24%)

  Fly     8 IALLVSLLLFMARRRHGYWQRRGI-------PHDVPHPIYGN--MKDWPKKRHIAMIFRDYYTKY 63
            :|.::||||.:.:....|..|:.:       |....|.::|:  :||        ...:|..|:.
Mouse    21 VASVLSLLLLLFKTAQLYLHRQWLLSSTQQFPSPPSHWLFGHKILKD--------QDLQDILTRI 77

  Fly    64 KRSVYPFAGFYFFFTRSAVIT--DLELVKRVLIKDFNHFENRGIFYNEIDDP------------L 114
            |.  :|.|...:.:.....|.  |.:.:|.:|.:               .||            :
Mouse    78 KN--FPSACPQWLWGSKVRIQVYDPDYMKLILGR---------------SDPKANGSYRFLAPWI 125

  Fly   115 SATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPII---VKVG-EEMEKIFSAKTTTGEGQVLEIV 175
            ...|..::||.|...|..|||.|....:|....|:   |:|. ::.|:|      .|:...|||.
Mouse   126 GRGLLMLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVRVMLDKWEQI------VGQDSTLEIF 184

  Fly   176 DLVARYTADVIGNCAFGLNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFGFPKLSRRLRLKL 240
            ..:...|.|.|..|||. :..|:|              ::|:|...:.
Mouse   185 RHITLMTLDTIMKCAFS-HEGSVQ--------------LDRKYKSYIQ----------------- 217

  Fly   241 NVQDVEDFYTSIVR-----NTIDYRLRTN--------EKRHDFMDSL-----IEMYEKEQA---- 283
            .|:|:.|...|.||     |.|.||:.:|        :..||..|.:     |::.::|:.
Mouse   218 AVEDLNDLVFSRVRNIFHQNDIIYRVSSNGCKANSACKLAHDHTDQVIKSRRIQLQDEEELEKLK 282

  Fly   284 -------------GNTEDG--LSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRA 333
                         ...|:|  ||..::.|:...|...|.:|:::.:.:..|.||.:.:.|.:.|.
Mouse   283 KKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRK 347

  Fly   334 EINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVV 398
            ||.::|. .....|:..:.:|.|....:.|.||.||.:..::|...:..:..|.: .:.||..|:
Mouse   348 EIQSLLG-DGTSITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTFPDGR-SLPKGIHVM 410

  Fly   399 IPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLI 463
            :...|:|::|.::|.||.|.|.||...  ::|.|.::|||..|.|||||.:|.:.:..|.:|..:
Mouse   411 LSFYGLHHNPTVWPNPEVFDPSRFAPG--SSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTL 473

  Fly   464 RGYKFSVSTETQIPMKFVVKSILLSAENGIHLKVEKL 500
            ..::. :...|::|:.  :..|:|.::|||||.::||
Mouse   474 LRFEL-LPDPTRVPIP--IPRIVLKSKNGIHLHLKKL 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	CYP6-like	68..494	CDD:410679	112/480 (23%)
Cyp4a12a	NP_803125.2	CYP4B-like	70..503	CDD:410771	117/494 (24%)