DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and Cyp4f6

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	XP_006241111.1	Gene:	Cyp4f6 / 266689	RGDID:	708365	Length:	538	Species:	Rattus norvegicus

Alignment Length:	484	Identity:	129/484 - (26%)
Similarity:	208/484 - (42%)	Gaps:	75/484 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 HIAMIFRDYYTKYKRSVYPFAGFYF------FFTRSAVITDLELVKRVLIKDFNHFENRGIFYNE 109
            |:...|||.:..:...|||......      ....||.:...|:.                .|..
  Rat    80 HLGRNFRDIHLSWVGPVYPILRLVHPNVIAPLLQASAAVAPKEMT----------------LYGF 128

  Fly   110 IDDPLSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEI 174
            :...|...|....|:||.|.|..|||.|....:|:...|..|....|...:...|..|..: |::
  Rat   129 LKPWLGDGLLMSAGEKWNHHRRLLTPAFHFDILKSYVKIFNKSVNTMHAKWQRLTAKGSAR-LDM 192

  Fly   175 VDLVARYTADVIGNCAFGLNCNSLQNPNAEFVTIGKRAIIE---------RRYGGLLDFLIF--- 227
            .:.::..|.|.:..|.|..:.| .|..|:|::.    ||:|         |:....||||.:
  Rat   193 FEHISLMTLDSLQKCIFSFDSN-CQESNSEYIA----AILELSSLIVKRQRQPFLYLDFLYYLTA 252

  Fly   228 ---GFPK-----------LSRRLRLKLNVQDVEDFYTSIVRNTIDYRLRTNEKRHDFMDSLIEMY 278
               .|.|           :.|..|..||.|.|::|          .:.|...|..||:|.|  :.
  Rat   253 DGRRFRKACDVVHNFTDAVIRERRSTLNTQGVDEF----------LKARAKTKTLDFIDVL--LL 305

  Fly   279 EKEQAGNTEDGLSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVL-SKH 342
            .|::.|.   |||..:|.|:|..|...|.:|:::.:.:.||.||...:.|::.|.|:..:| .:.
  Rat   306 AKDEHGK---GLSDVDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVRELLRDRE 367

  Fly   343 NNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYD 407
            ..|..::.:.::.:|...:.|:||.:|.:..::|....|....|.: .|.||...||...|:|::
  Rat   368 PEEIEWDDLAQLPFLTMCIKESLRLHPPVLLISRCCSQDIVLPDGR-VIPKGNICVISIFGVHHN 431

  Fly   408 PEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVST 472
            |.::|:||.:.|.||..|....|....::||..|||||||..|.:.:..|.||..:  .:|.|..
  Rat   432 PSVWPDPEVYNPFRFDPENPQKRSPLAFIPFSAGPRNCIGQTFAMSEIKVALALTL--LRFCVLP 494

  Fly   473 ETQIPMKFVVKSILLSAENGIHLKVEKLS 501
            :.:.|.:  ...::|.||.|:.|:||.||
  Rat   495 DDKEPRR--KPELILRAEGGLWLRVEPLS 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	124/476 (26%)
Cyp4f6	XP_006241111.1	p450	53..515	CDD:278495	124/476 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910