DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and Cyp3a2

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_695224.3	Gene:	Cyp3a2 / 266682	RGDID:	708379	Length:	504	Species:	Rattus norvegicus

Alignment Length:	510	Identity:	174/510 - (34%)
Similarity:	267/510 - (52%)	Gaps:	48/510 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMIFRDYYTKYKRSVYPFA 71
            |:|:::.||..:...|||.::::|||...|.|..|.:.::.|  .:.....:.|.||.:    ..
  Rat    14 LLAVILVLLYRLGTHRHGIFKKQGIPGPKPLPFLGTVLNYYK--GLGRFDMECYKKYGK----IW 72

  Fly    72 GFYFFFTRSAVITDLELVKRVLIKD-FNHFENR------GIFYNEIDDPLSATLFSIEGQKWRHL 129
            |.:...|....|.|.|::|.||:|: |:.|.||      ||        :...:...:.::|:..
  Rat    73 GLFDGQTPVFAIMDTEMIKNVLVKECFSVFTNRRDFGPVGI--------MGKAVSVAKDEEWKRY 129

  Fly   130 RHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNCAFGLN 194
            |..|:||||||::|.|||||.:.|:.:.|....:..||:...::.|  ...|:.|||.:.:||:|
  Rat   130 RALLSPTFTSGRLKEMFPIIEQYGDILVKYLKQEAETGKPVTMKKV--FGAYSMDVITSTSFGVN 192

  Fly   195 CNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFG--------FPKLS---RRLRLKLNVQDVEDF 248
            .:||.||...||...|:         ||.|..|.        ||.|:   ..|.:.:..:|...|
  Rat   193 VDSLNNPKDPFVEKTKK---------LLRFDFFDPLFLSVVLFPFLTPIYEMLNICMFPKDSIAF 248

  Fly   249 YTSIVRNTIDYRLRTNEK-RHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFETSST 312
            :...|....:.||.:..| |.||:..::..:...:...:...||..||:||:.||..||:||:|:
  Rat   249 FQKFVHRIKETRLDSKHKHRVDFLQLMLNAHNNSKDEVSHKALSDVEIIAQSVIFIFAGYETTSS 313

  Fly   313 TMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRM 377
            |:.|.||.||...|||.:|:.||:..|...... ||:.:.||:||:.|:.||||.||:...|.|:
  Rat   314 TLSFVLYFLATHPDIQKKLQEEIDGALPSKAPP-TYDIVMEMEYLDMVLNETLRLYPIGNRLERV 377

  Fly   378 TQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGP 442
            .:.|.  |....||.||:.|.||...:|:||:.:|:||:|.||||:.|...:.....:||||.||
  Rat   378 CKKDI--ELDGLFIPKGSVVTIPTYALHHDPQHWPKPEEFHPERFSKENKGSIDPYVYLPFGNGP 440

  Fly   443 RNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKV 497
            |||||:||.||...:.|..:::.:.|....|||||:| :.:..:|..|..|.|||
  Rat   441 RNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLK-LSRQAILEPEKPIVLKV 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	161/477 (34%)
Cyp3a2	NP_695224.3	CYP3A	67..493	CDD:410743	156/452 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870