DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a23 and Cyp4a8

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	XP_038965258.1	Gene:	Cyp4a8 / 266674	RGDID:	628846	Length:	510	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	133/548 - (24%)
Similarity:	237/548 - (43%)	Gaps:	107/548 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLLLTLIALLVSLLLFMARRRHGYWQRRG---IPHDVPHPIYGNMKDWPKKRHIAMIFRDYYTK 62
            ::.:||::.||.....|...||   |..|.   .|....|..:|:...:    .:...|:|..|:
  Rat    21 IATVLTVLLLLFKTAQFYLHRR---WLLRATQQFPSPPSHWFFGHKLSF----LVDQEFQDILTR 78

  Fly    63 YKRSVYPFAGFYFFFTRSAVIT--DLELVKRVLIKD--FNHFENRGIFYNEIDDPLSATLFSIEG 123
            .|.  :|.|...:.:..:..|.  |.:.:|.:|.:.  .:|..     |..:...:...|..:.|
  Rat    79 VKN--FPSACPQWLWGSNVRIQVYDPDYMKLILGRSDPKSHHS-----YRFLAPWIGYGLLLLNG 136

  Fly   124 QKWRHLRHKLTPTFTSGKMKNMFPII---VKVG-EEMEKIFSAKTTTGEGQVLEIVDLVARYTAD 184
            |.|...|..|||.|....:|....|:   |::. ::.|:|      .|:...|||...:...|.|
  Rat   137 QTWFQHRRMLTPAFHYDTLKPYVGIMADSVRIMLDKWEQI------VGQDSTLEIFQHITLMTLD 195

  Fly   185 VIGNCAFGLNCNSLQNPNAEFVTIGKRAIIERRYGGL---------LDF-----------LIFGF 229
            .|..|||... .|:|              ::|:|...         |.|           :|:..
  Rat   196 TIMKCAFSQE-GSVQ--------------LDRKYKSYIKAVEDLNNLSFFRIRNIFHQNDIIYSL 245

  Fly   230 PKLSRRLR----------------LKLNVQDVEDFYTSIVRNTIDYRLRTNEKRH-DFMDSLIEM 277
            ....|:.|                .|..:||.|:..            :..:||. ||:|.|  :
  Rat   246 SSNGRKARSAWQLAHEHTDQVIKSRKAQLQDEEELQ------------KVKQKRRLDFLDIL--L 296

  Fly   278 YEKEQAGNTEDGLSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKH 342
            :.:.:.|::   ||..::.|:...|...|.:|:::.:.:..|.||.:.:.|...|.||.::|. .
  Rat   297 FARIENGSS---LSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQGCRKEIQSLLG-D 357

  Fly   343 NNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYD 407
            ....|::.:.:|.|....:.|.||.||.:..::||..|..:..|.: .:.||.||::...|:|::
  Rat   358 GASITWDDLDKMPYTTMCIKEALRIYPPVTAVSRMLSTPVTFPDGR-SLPKGITVMLSFYGLHHN 421

  Fly   408 PEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVST 472
            |.::|.||.|.|.||..|  ::|.|.::|||..|.|||||.:|.:.:..|.:|..:..::. :..
  Rat   422 PTVWPNPEVFDPYRFAPE--SSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFEL-LPD 483

  Fly   473 ETQIPMKFVVKSILLSAENGIHLKVEKL 500
            .|:||:.  :..::|.::|||:|:::||
  Rat   484 PTRIPIP--IPRLVLKSKNGIYLRLKKL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	120/503 (24%)
Cyp4a8	XP_038965258.1	CYP4B-like	72..505	CDD:410771	118/484 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910